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  • 首页 > 抗体类 > 一抗 > bs-4593R,bioss,基质金属蛋白酶9抗体 MMP9
bs-4593R,bioss,基质金属蛋白酶9抗体 MMP9

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  • bs-4593R,bioss,基质金属蛋白酶9抗体 MMP9

bs-4593R,bioss,基质金属蛋白酶9抗体 MMP9

品牌:Bioss/博奥森 | 货号:bs-4593R
  • 所属大类 : 抗体类
  • 所属小类 : 一抗
  • 品牌 : Bioss/博奥森
  • 规格 : 50ul
  • 原价 : ¥1098.00
  • 促销价 : ¥980.00
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    产品编号 bs-4593R
    英文名称 MMP9
    中文名称 基质金属蛋白酶9抗体
    别    名 Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; Collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; Collagenase Type 4 beta; Collagenase Type-4 beta; Collagenase type IV 92 KD; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase.  
    Specific References  (24)     |     bs-4593R has been referenced in 24 publications.
    [IF=5.1] Yu, Chengyuan, et al. "Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway." Oncotarget 8.23 (2017): 37705.  WB, IHC-P ;  Dog.  
    PubMed:28465478
    [IF=4.776] Ma F et al. In situ fabrication of a composite hydrogel with tunable mechanical properties for cartilage tissue engineering. J. Mater. Chem. B, 2019.  WB ;  Human.  
    PubMed:10.1039/C8TB01331D
    [IF=4.26] Parveen et al. Unconventional MAPK-GSK-3β Pathway Behind Atypical Epithelial-Mesenchymal Transition In Hepatocellular Carcinoma. (2017) Sci.Re. 7:8842  WB ;  Human.  
    PubMed:28821798
    [IF=3.775] Chen Z et al. Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. Food Chem Toxicol. 2019 Aug;130:1-11.   WB ;  Human.  
    PubMed:31054290
    [IF=3.457] Chai FN et al. Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.Biomed Pharmacother. 2018 Jul;103:1002-1011.  WB ;  Mouse.  
    PubMed:29710498
    [IF=3.457] Li W et al. Upregulation of MMP-9 and CaMKII prompts cardiac electrophysiological changes that predispose denervated transplanted hearts to arrhythmogenesis after prolonged cold ischemic storage. Biomed Pharmacother. 2019 Feb 20;112:108641.   WB ;  Rat.  
    PubMed:30784925
    [IF=3.361] Varghese S et al. Immunostimulatory plant polysaccharides impede cancer progression and metastasis by avoiding off-target effects. Int Immunopharmacol. 2019 May 21;73:280-292.  WB ;  Human.  
    PubMed:31125927
    [IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017).  WB ;  Human.  
    PubMed:28552725
    [IF=2.976] Chen X et al. Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells.(2019)Oncol Rep. Feb;41(2):765-778.  WB ;  
    PubMed:30431140
    [IF=2.94] Deng, XiaHeng, et al. "MiR-21 involve in ERK-mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia." Brain Research Bulletin (2013).  WB ;  Rat.  
    PubMed:23473787
    [IF=2.54] Wang, Li, et al. "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." Peptides (2017).  IHC-P ;  Rabbit.  
    PubMed:28189525
    [IF=2.52] Liu, Tianbo, et al. "Correlation of TNFAIP8 overexpression with the proliferation, metastasis, and disease-free survival in endometrial cancer." Tumor Biology (2014): 1-10.  IHC-P ;  Human.  
    PubMed:24590269
    [IF=2.25] Yang X et al.Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration and invasion, and promotes apoptosis in pancreatic cancer cells. (2018)Biochem. Cell Biol.   WB ;  Human.  
    PubMed:30359541
    [IF=2.25] Shi S et al. MicroRNA-34a attenuates VEGF-mediated retinal angiogenesis via targeting the Notch1.(2018) Biochemistry and Cell Biology   WB ;  Rat &Human.  
    PubMed:30571142
    [IF=2.25] Fan S et al.Carboxypeptidase E-ΔN promotes migration, invasion and epithelial-mesenchymal transition of human osteosarcoma cell lines through the Wnt/β-catenin pathway.(2018) Biochem Cell Biol.   WB ;  Human.  
    PubMed:30508384
    [IF=2.11] Lee et al. Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-κB signaling pathways. (2017) Mol.Vi. 22:1490-1502  WB ;  Human.  
    PubMed:28050122
    [IF=1.93] Lee, Hye Sook, et al. "Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits." Graefes Archive for Clinical and Experimental Ophthalmology (2014): 1-11.  IHC-P ;  Rabbit.  
    PubMed:24789464
    [IF=1.68] Wang et al. The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment. (2017) J.Ophthalmol. 2017:6067891  IHC ;  Rabbit.  
    PubMed:28280636
    [IF=1.55] Yang, Jinjiang, Ying Lu, and Ai Guo. "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." Molecular Medicine Reports 14.5 (2016): 4075-4082.  WB ;  Rat.  
    PubMed:27665780
    [IF=1.466] Yan B et al. Suppression of puerarin on polymethylmethacrylate-induced lesion of peri-implant by inhibiting NF-κB activation in vitro and in vivo.Pathol Res Pract. 2019 Mar 1:152372.   WB ;  Mouse.  
    PubMed:30853175
    [IF=1.43] Wang, Xiao-yan, et al. "AMD3100 attenuates MMP-3 and MMP-9 expressions and prevents cartilage degradation in a monosodium iodoacetate-induced rat model of temporomandibular osteoarthritis." Journal of Oral and Maxillofacial Surgery (2016).  IHC-P ;  Rat.  
    PubMed:26851314
    [IF=1.39] He et al. Long non-coding RNA SPRY4-IT1 promotes the proliferation and invasion of U251 cells through upregulation of SKA2. (2018) Oncol.Lett. 15:3977-3984  WB ;  Human.  
    PubMed:29467908
    [IF=0] Wang, Menglei, et al. "The Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Anterior Segment." Journal of Ophthalmology 2017 (2017).  IHC-P ;  Rabbit.  
    PubMed:28280636
    [IF=0] Ye T et al. MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer. J Exp Clin Cancer Res. 2019 Feb 6;38(1):55.  FCM&IHC ;  Mouse&Human.  
    PubMed:30728051
    研究领域 肿瘤  细胞生物  免疫学  神经生物学  信号转导  转录调节因子  合成与降解  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 78kDa
    细胞定位 细胞外基质 分泌型蛋白 
    性    状 Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human MMP9:151-250/707 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
    PubMed PubMed
    产品介绍 All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn(2+) binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.

    Function:
    May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

    Subunit:
    Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.

    Subcellular Location:
    Secreted, extracellular space, extracellular

    Tissue Specificity:
    Produced by normal alveolar macrophages and granulocytes.

    Post-translational modifications:
    Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
    N- and O-glycosylated.

    DISEASE:
    Defects in MMP9 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.
    Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.

    Similarity:
    Belongs to the peptidase M10A family.

    SWISS:
    P14780

    Gene ID:
    4318

    Database links:

    Entrez Gene: 403885 Dog

    Entrez Gene: 4318 Human

    Entrez Gene: 17395 Mouse

    Entrez Gene: 81687 Rat

    Omim: 120361 Human

    SwissProt: O18733 Dog

    SwissProt: P14780 Human

    SwissProt: P41245 Mouse

    SwissProt: P50282 Rat

    Unigene: 297413 Human

    Unigene: 4406 Mouse

    Unigene: 10209 Rat




    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    MMP9亦称IV型胶原酶或明胶酶B,其主要功能为降解IV型胶原。因而它在肿瘤细胞突破基底膜屏障和浸润转移中起重要作用。目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与转移浸润的研究。细胞外基质在维持正常组织结构与功能以及细胞生长和分化过程中起重要作用。细胞外基质动态平衡的失调与肿瘤细胞侵袭、转移和复发密切相关,基质金属蛋白酶(MMP9)是细胞外基质的降解酶,可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型胶原,在肿瘤的浸润、转移过程中起重要作用,近年为肿瘤研究的热点。
    产品图片
    Sample: A549 Cell (Human) Lysate at 40 ug
    Primary: Anti-MMP9 (bs-4593R) at 1/300 dilution
    Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution
    Predicted band size: 78 kD
    Observed band size: 70 kD
    十二烷基磺酸钠与十二烷基硫酸钠的区别
    实验室中的化学试剂的防护之十二烷基硫酸钠
    十二烷基硫酸钠(SDS)的生物应用
    十二烷基硫酸钠 SDS说明书暂时没有说明书
    1.《Multifunction Sr, Co and F co-doped microporous coating on titanium of antibacterial, angiogenic and osteogenic activities》
    作者:Jianhong Zhou ,Lingzhou Zhao 影响因子:4.259
    期刊:《Scientific Reports 6, Article number: 29069 (2016)》 PMID:27353337

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