产品细节图:

维生素C

品牌：Solarbio/索莱宝 | 货号：IA0530-20mg

所属大类 : 试剂

所属小类 : 小分子化合物

品牌 : Solarbio/索莱宝

规格 : 20mg

原价 : ￥240.00

促销价 : ￥240.00

维生素C

产品简介

CAS	50-81-7
中文名称	维生素C
英文名称	L-Ascorbic Acid
别名	L(+)-Ascorbic acid;Vitamin C;L-抗坏血酸
纯度	HPLC≥98%
分子式	C₆H₈O₆
分子量	176.12
外观（性状）	White to off-white Solid
储存条件	Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
溶解性	Soluble in Water ≥20mg/mL
MDL	MFCD00064328
EC	EINECS 200-066-2
InChIKey	CIWBSHSKHKDKBQ-JLAZNSOCSA-N
InChI	InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
PubChem CID	54670067
SMILES	OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
描述	L-Ascorbic Acid是一种有效的还原剂和抗氧化剂。(L-Ascorbic Acid is a potent reducing agent and antioxidant.)
生物活性	L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[1].
In Vitro	The anti-cancer effects of L-Ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-ascorbic acid. L-Ascorbic acid (0.1 μM-2 mM) exhibits anti-cancer effects according to SVCT-2 expression and L-ascorbic acid uptake. Human colorectal cancer cell lines displays differential responses to L-ascorbic acid, primarily depending on the expression level of SVCT-2[1].
In Vivo	L-Ascorbic acid/Tolbutamide produces hypoglycaemic activity in a dose dependant manner in normal (60 mg/kg) and diabetic (40 mg/kg) condition. In the presence of L-ascorbic acid, Tolbuatmide (20 mg/kg) produces early onset of action and maintained for longer period compared to Tolbutamide matching control[2].
数据来源文献	[1]. Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372. [2]. Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2.
规格	20mg 10mM*1mL (in Water) 100mg
单位	瓶

一种重要的营养素和氧化还原剂，在骨盐代谢及骨形成中具有重要作用。在体外，它能增加钙盐的沉积，促进矿化结节的形成，并通过间充质细胞间接调节破骨细胞的分化。维生素C能直接抑制核因子κB受体活化子配体（RANKL）诱导的破骨细胞形成。

使用本产品的应用案例（仅供参考）

In Vitro

Cell（Osteogenic/成骨诱导；50 mg/l ascorbic acid）

The osteogenic medium was the complete culture medium supplemented with 10 nM dexamethasone(Solarbio), 10 mM β-glycerophosphate (Solarbio), and 50 mg/l ascorbic acid (Solarbio).

数据来源文献：Jia L, Zhang Y, Ji Y, Li X, Xing Y, Wen Y, Huang H, Xu X. Comparative analysis of lncRNA and mRNA expression profiles between periodontal ligament stem cells and gingival mesenchymal stem cells. Gene. 2019 May 30;699:155-164. doi: 10.1016/j.gene.2019.03.015. Epub 2019 Mar 12. PMID: 30876821.

Cell（Osteogenic/成骨诱导；50 mg/l ascorbic acid）

Osteogenic induced medium contained complete culture medium supplemented with 100 nM dexamethasone (Solarbio, Beijing, China), 10 mM β-glycerophosphate (Solarbio) and 50 mg/l ascorbic acid (Solarbio). The medium was replaced every other day. Alizarin Red–positive mineralized matrix was used to evaluate osteogenic capacity by Alizarin red (AR) staining.

数据来源文献：Zhao Y, Liu H, Xi X, Chen S, Liu D. TRIM16 protects human periodontal ligament stem cells from oxidative stress-induced damage via activation of PICOT. Exp Cell Res. 2020 Dec 1;397(1):112336. doi: 10.1016/j.yexcr.2020.112336. Epub 2020 Oct 19. PMID: 33091421.

In Vivo

Rat（雄性新生SD Rat；100 mg vitamin C/kg bw/d；灌胃；30d）

Forty-five male neonatal SD rats were randomly divided into five groups (n=9 each): corn oil control group, 500 mg DEHP/kg of body weight per day (bw/d) group, 500 mg DEHP/kg bw/d+200 mg vitamin E/kg bw/d group, 500 mg DEHP/kg bw/d+100 mg vitamin C/kg bw/d group, and 500 mg DEHP/kg bw/d+200 mg vitamin E/kg bw/d+100 mg vitamin C/kg bw/d group. DEHP and vitamin E (Solarbio, China) were dissolved in corn oil, and vitamin C (Solarbio,China) was dissolved in distilled water. From postnatal day (PND) 1 to 30, the male rats were administered corn oil, DEHP, vitamin C, and/or vitamin E by gavage each day according to their group. On PND 36, six rats of each groups were sacrificed and their testes were immediately isolated. The rest of rats were fed with routine feed until PND 90.

来源文献：Tang X, Wu S, Shen L, Wei Y, Cao X, Wang Y, Long C, Zhou Y, Li D, Huang F, Liu B, Wei G. Di-(2-ethylhexyl) phthalate (DEHP)-induced testicular toxicity through Nrf2-mediated Notch1 signaling pathway in Sprague-Dawley rats. Environ Toxicol. 2018 Jul;33(7):720-728. doi: 10.1002/tox.22559. Epub 2018 Apr 16. PMID: 29663635.

备注：

以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。

These protocols are for reference only. Solarbio does not independently validate these methods

十二烷基磺酸钠与十二烷基硫酸钠的区别
实验室中的化学试剂的防护之十二烷基硫酸钠
十二烷基硫酸钠（SDS）的生物应用

暂时没有说明书

1.《Multifunction Sr, Co and F co-doped microporous coating on titanium of antibacterial, angiogenic and osteogenic activities》
作者：Jianhong Zhou ,Lingzhou Zhao 影响因子：4.259
期刊：《Scientific Reports 6, Article number: 29069 (2016)》 PMID：27353337

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维生素C

品牌：Solarbio/索莱宝 | 货号：IA0530-20mg

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