显示面板屏幕尺寸为7英寸液晶触摸屏，可直观的进行操作及显示各种与设备相关的信息；报警系统具备高低温报警、传感器故障报警、冷凝器脏堵报警、环温异常报警、电压异常报警、断电报警、门开报警、电池电量低报警、远程报警接口，所有的报警信息以及历史记录可在液晶屏查询。USB数据存储功能具备USB数据存储功能，可存储10年以上的数据，方便查询历史记录；双机复叠技术，耐43℃环境温度，超保温

METHER高端系列-86/-150℃超低温保存箱 MDF-86V408

货号：MDF-86V408

品牌：中科都菱

基本售价：

0.00元

控温方式触控屏温度控制系统，控制更精确，温度数字与曲线双显示。温度-10~-86℃自由调节，满足不同物品不同温区存放，采用优质工业设备专用电阻式7英寸触控屏，防尘、防水汽双测试孔/温度打印标配双测试孔，USB接口以及远程报警接口，USB具有数据导出功能，配备热敏温度记录打印机，数据浏览功能可随时掌握运行周期状况：完善的声光报警功能高温、低温、开门、过滤网堵塞、系统故障、传感器故障、环温高报警等报警功能，确保箱内物品存放安全；密码保护功能系统，防止随意调整运行参数；双机复叠技术，传统技术稳定性安全可靠，C/H制冷剂绿色无污染，更节能，第二代VIP技术，保温性能好，减小占地面积，样本储存量最优

METHER高端系列-86/-150℃超低温保存箱 MDF-86V838D（双系统）

货号：MDF-86V838D

品牌：中科都菱

基本售价：

0.00元

双重保障采用两套独立的制冷系统，其中一套故障时，另一套可维持-70℃的柜内温度快速降温双系统同时工作能实现快速降温，降温时间缩短50%以上智能控温触摸屏，温度曲线、报警信息记录及查询，用户管理模式，自我诊断

产品编号bs-0081R英文名称Caspase-3中文名称活化半胱胺酸蛋白酶蛋白-3抗体别名Caspase-3 subunit p17; cleaved Caspase 3; cleaved Caspase-3; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cleavage activity 1; SCA-1. Specific References (117) | bs-0081R has been referenced in 117 publications.[IF=9.91] Li, Ting, et al. "Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke." Brain (2013): awt287. Mouse. PubMed:24154617 [IF=8.355] Chen Z et al. Enzyme-powered Janus nanomotors launched from intratumoral depots to address drug delivery barriers. Chemical Engineering Journal,2019 375, 122109. IHC ; Mouse. PubMed:doi:10.1016/j.cej.2019.122109 [IF=7.6] Teng, I., et al. "Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer." Biomaterials (2013). WB ; Mouse. PubMed:23810081 [IF=7.05] He, Nan, et al. "Tumor pH-responsive Release of Drug-conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy." ACS Applied Materials & Interfaces (2017). other ; PubMed:28876891 [IF=6.375] Zhou,et al.CXCR4 antagonist AMD3100 enhances the response of MDA-MB-231 triple-negative breast cancer cells to ionizing radiation.(2018) Cancer Letters. 418:196-203. IHC-P + WB ; Mouse. PubMed:29317253 [IF=6.217] Wang L et al. Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways. J Exp Clin Cancer Res. 2019 Feb 21;38(1):93. WB ; Mouse. PubMed:30791957 [IF=6.01] Chen, Zhoujiang, et al. "Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release." Acta Biomaterialia (2016). IHC-P ; Mouse. PubMed:27424081 [IF=5.47] Pan, Bo, et al. "c-Abl Tyrosine Kinase Mediates Neurotoxic Prion Peptide-Induced Neuronal Apoptosis via Regulating Mitochondrial Homeostasis." Molecular Neurobiology (2014): 1-15. Rat. PubMed:24510275 [IF=5.23] Zhao, Yong, et al. "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." Scientific Reports 6 (2016): 37884. WB ; Pig. PubMed:27883089 [IF=5.154] Wu et al. Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats. (2017) Front.Mol.Neurosc. 10:175 WB ; Rat. PubMed:28634441 [IF=5.1] Wang, Caixia, et al. "Oral 4-(N)-stearoyl gemcitabine nanoparticles inhibit tumor growth in mouse models." Oncotarget 8.52 (2017): 89876-89886. IHC-P ; Mouse. PubMed:29163795 [IF=5.1] Wang, Caixia, et al. "Oral 4-(N)-stearoyl gemcitabine nanoparticles inhibit tumor growth in mouse models." Oncotarget 8.52 (2017): 89876-89886. IHC-P ; Mouse. PubMed:29163795 [IF=5.047] Chen Z et al. Synergistic antitumor efficacy of hybrid micelles with mitochondrial targeting and stimuli-responsive drug release. Journal of Materials Chemistry B.2019. IHC-P ; Human. PubMed: doi:10.1039/c8tb02843e [IF=5] Li, Bo, et al. "Long noncoding RNA CCAT1 functions as a ceRNA to antagonize the effect of miR-410 on the down-regulation of ITPKB in human HCT-116 and HCT-8 cells." Oncotarget 8.54 (2017): 92855. WB ; Human. PubMed:29190961 [IF=4.94] Kubatka, Peter, et al. "Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma." Journal of Cellular and Molecular Medicine (2017). IHC-P ; Rat. PubMed:28524540 [IF=4.75] Rosenzweig, Derek H., Sing J. Ou, and Thomas M. Quinn. ʺP38 mitogen‐activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.ʺ Journal of Cellular and Molecular Medicine (2013) WB ; Bovine. PubMed:23480786 [IF=4.525] Truffi,et al.Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn's Disease Strictures Ex Vivo.(2018) Inflammatory Bowel Diseases. 24:332-345. IF(IHC-F) ; Human. PubMed:29361086 [IF=4.38] Ma, Xiangyi, et al. "DT390-triTMTP1, a novel fusion protein of diphtheria toxin with tandem repeat TMTP1 peptide, preferentially targets metastatic tumors." Molecular pharmaceutics 10.1 (2013): 115-126. IHC-P ; Human. PubMed:23198829 [IF=4.28] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017). IHC-P ; Mouse. PubMed:29202267 [IF=4.26] Rosenzweig, Derek H., et al. "Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis." Osteoarthritis and Cartilage (2012). WB ; Bovine. PubMed:22935788 [IF=4.254] Gao L et al. Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death. Lab Invest. 2018 Jul;98(7):911-923. WB ; Mouse. PubMed:29581579 [IF=4.22] Sondag, Gregory R., et al. "Osteoactivin Induces Transdifferentiation of C2C12 Myoblasts into Osteoblasts." Journal of Cellular Physiology (2013). Mouse. PubMed:24265122 [IF=4.2] Tian, A., et al. "Nanoscale TiO 2 nanotubes govern the biological behavior of human glioma and osteosarcoma cells." International Journal of Nanomedicine10 (2015): 2377-2389. Human. PubMed:25848261 [IF=4.12] Wang et al. Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation. (2016) Sci.Rep. 6:36543 WB ; Human. PubMed:27824118 [IF=3.974] Liao J et al. Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes.Ecotoxicol Environ Saf. 2019 Jun 15;174:110-119. WB ; Chicken. PubMed:30822667 [IF=3.95] Wang, Gang, et al. "Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway." Apoptosis (2013): 1-15. IHC-P ; Rat. PubMed:23054084 [IF=3.923] Song LL et al. TGF-β and HSP70 profiles during transformation of yak hair follicles from the anagen to catagen stage. J Cell Physiol. 2019 Feb 5. WB ; Yak. PubMed:30723905 [IF=3.92] Wei, Gang, et al. "β-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice." Journal of Alzheimer's Disease 33.3 (2013): 863-880. IF(ICC) ; Mouse. PubMed:23064259 [IF=3.909] Zhu B et al. The hepatoprotective effect of polysaccharides from Pleurotus ostreatus on carbon tetrachloride-induced acute liver injury rats.Int J Biol Macromol. 2019 Jun 15;131:1-9. IHF ; Rat. PubMed:30851331 [IF=3.85] Wang, Yandi, et al. "Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis." Toxicology and Applied Pharmacology (2016). IHC-P ; Sheep. PubMed:27815134 [IF=3.84] Kubatka, Peter, et al. "Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer." European Journal of Nutrition(2015): 1-11. IHC-P ; Rat. PubMed:25930965 [IF=3.83] Yang et al. MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway. (2018) Front.Pharmacol. 8:980 WB ; Mouse. PubMed:29375381 [IF=3.82] Clark, Andrea J., et al. "WO3/Pt nanoparticles are NADPH oxidase biomimetics that mimic effector cells in vitro and in vivo." Nanotechnology27.6 (2015): 065101. PubMed:26683660 [IF=3.79] Luo, Xiaoming, et al. "Antimetastasis and antitumor efficacy promoted by sequential release of vascular disrupting and chemotherapeutic agents from electrospun fibers." International Journal of Pharmaceutics (2014). IHC-P ; Mouse. PubMed:25218185 [IF=3.687] Kubatka P et al. Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro. Int J Mol Sci. 2019 Apr 9;20(7). pii: E1749. IHC-P ; Rat&Mouse. PubMed:30970626 [IF=3.68] Xiao, Ke, et al. "The role of visfatin on the regulation of inflammation and apoptosis in the spleen of LPS-treated rats." Cell and Tissue Research (2014). IHC-P ; Rat. PubMed:25358398 [IF=3.53] Fang C, Zhang J, Qi D, Fan X, Luo J, et al. (2014) Evodiamine Induces G2/M Arrest and Apoptosis via Mitochondrial and Endoplasmic Reticulum Pathways in H446 and H1688 Human Small-Cell Lung Cancer Cells. PLoS ONE 9(12): e115204. WB ; Human. PubMed:25506932 [IF=3.52] Chu et al. Newcastle Disease Virus V Protein Inhibits Cell Apoptosis and Promotes Viral Replication by Targeting CacyBP/SIP. (2018) Front.Cell.Infect.Microbiol. 8:304 WB ; PubMed:30234028 [IF=3.47] Kubatka, Peter, et al. "Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model." European Journal of Nutrition (2016): 1-14. IHC-P ; Rat. PubMed:26907089 [IF=3.448] Xu B et al. Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anteriorcruciate ligament-transected rat osteoarthritis model. Life Sci. 2019 Jul 1;228:158-166. WB ; Rat. PubMed:31055086 [IF=3.412] Chen S et al. Anthocyanins from Lycium ruthenicum Murr. ameliorated D-galactose-induced memory impairment, oxidative stress, and neuroinflammation in adult rats.J Agric Food Chem. 2019 Mar 20;67(11):3140-3149. WB&IHC-P ; Rat. PubMed:30813721 [IF=3.4] Gao, Hui, et al. "Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer."American Journal of Translational Research 8.2 (2016): 1115-1132 WB ; Human. PubMed:27158398 [IF=3.23] Wang, Yu, et al. "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." PloS one 12.4 (2017): e0173469. WB ; Rat. PubMed:28399139 [IF=3.17] Liu, Yang, et al. "Amelioration of Stroke-Induced Neurological Deficiency by Lyophilized Powder of Catapol and Puerarin." International Journal of Biological Sciences 10.4 (2014): 448-456. WB ; Mouse. PubMed:24719562 [IF=3.156] Andharia,et al.Electrophysiological properties of anion exchangers in the luminal membrane of guinea pig pancreatic duct cells.(2018) Pflugers Archiv: European Journal of Physiology. 470:897-907. IHC-P + WB ; Guinea Pig. PubMed:29399744 [IF=3.138] Chen J et al. Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro.Saudi J Biol Sci. 2018 Nov;25(7):1488-1493. WB&IHC ; Rat. PubMed:30505200 [IF=3.13] Zhang, Wen-feng, et al. "Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo." Phytomedicine (2017). WB ; Human. PubMed:28887916 [IF=3.105] Yang F et al. Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes.(2019)Toxicol In Vitro. Feb;54:310-316. WB ; Chicken. PubMed:30389602 [IF=3.06] Li, Guiying, et al. ʺGremlin Aggravates Hyperglycemia‐Induced Podocyte Injury by a TGFβ/Smad Dependent Signaling Pathway.ʺ Journal of CellularBiochemistry (2013). WB ; Mouse. PubMed:23553804 [IF=3.043] Chen Y et al. Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice.(2018)Cell Tissue Res.Nov 9. IHC ; Mouse. PubMed:30413887 [IF=2.959] Song, D. et al. Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo. (2018) Journal of Cellular Biochemistry. WB ; Rat. PubMed:10.1002/jcb.27420 [IF=2.903] Wang C et al. Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1. (2018) Vet Res. 49(1):102. WB ; chicken embryos. PubMed:30290847 [IF=2.9] Shan, Ming, and Ting-Jun Fan. "Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway." Toxicology in Vitro (2016). ELISA ; Human. PubMed:27216471 [IF=2.86] Liu, Yaping, et al. "Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice." International Journal of Molecular Sciences 17.1 (2016): 96. WB ; Mouse. PubMed:26771609 [IF=2.85] Xu et al. Resveratrol controlled the fate of porcine pancreatic stem cells through the Wnt/β-catenin signaling pathway mediated by Sirt1. (2017) PLoS.On. 12:e0187159 WB ; Pig. PubMed:29073244 [IF=2.791] Wang Q et al. Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10. 8-induced cell cycle arrest and apoptosis. Vet Microbiol. 2019 Jun 28;235:151-163. WB ; Monkey. PubMed:31282373 [IF=2.75] Ye, Bengui, et al. "Anti-tumor activity and relative mechanism of ethanolic extract of Marsdenia tenacissima (Asclepiadaceae) against human hematologic neoplasm in vitro and in vivo." Journal of Ethnopharmacology (2014). WB ; Human. PubMed:24583069 [IF=2.7] Lv, Runxiao, et al. "Neuroprotective effect of allicin in a rat model of acute spinal cord injury." Life Sciences (2015). WB ; Rat. PubMed:26546416 [IF=2.69] Lin, Caiyu, et al. "Lithocarpus Polystachyus Rehd Leaf Aqueous Extract Inhibits Human Breast Cancer Growth In Vitro and In Vivo." Nutrition and Cancer (2014). WB ; Human. PubMed:24660968 [IF=2.656] Liu et al. Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells. (2018) Onco.Targets.Ther. 11:6569-6577 WB ; PubMed:30323629 [IF=2.61] Lei, Mingxing, et al. ʺGsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes.ʺ Histochemistry and cell biology 138.3 (2012): 385-396. WB, IHC-P ; Mouse. PubMed: 22585037 [IF=2.561] Peng X et al. Overexpression of modified human TRβ1 suppresses the growth of hepatocarcinoma SK-hep1 cells in vitro and in xenograft models.Mol Cell Biochem. 2018 Dec;449(1-2):207-218. IHC-P&WB ; Mouse&Human. PubMed:29679278 [IF=2.535] Chen J et al. Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy. Biosci Rep. 2019 Jul 8. pii: BSR20190578. WB&IHC ; Rat. PubMed:31285389 [IF=2.53] Yoshinaga, Ayana, et al. "NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation." European Journal of Pharmacology (2016). WB ; Human. PubMed:27105818 [IF=2.52] Yao, Kun, et al. "Knockdown of RLIP76 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to daunorubicin in U937 leukemia cells." Tumor Biology (2014): 1-9. WB ; Human. PubMed:24839008 [IF=2.498] Du J et al. MicroRNA-204-5p regulates 3T3-L1 preadipocyte proliferation, apoptosis and differentiation.Gene. 2018 Aug 20;668:1-7. ICF ; Mouse. PubMed:29775748 [IF=2.491] Şahin S et al. Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.(2018) Epilepsy Res.149 IHC-P ; Rat . PubMed:30584976 [IF=2.41] Guan, Junhong, et al. "Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain." Biochemical and Biophysical Research Communications (2013). WB ; Rat. PubMed:24184479 [IF=2.38] Gao, Hui, et al. "Hispidulin Potentiates the Antitumor Effect of Sunitinib Against Human Renal Cell Carcinoma in Laboratory Models." Cell Biochemistry and Biophysics: 1-8. WB ; Human. PubMed:25260394 [IF=2.38] Gao, Hui, et al. "shRNA-Mediated EMMPRIN Silencing Inhibits Human Leukemic Monocyte Lymphoma U937 Cell Proliferation and Increases Chemosensitivity to Adriamycin." Cell Biochemistry and Biophysics: 1-9. WB ; Human. PubMed:25260396 [IF=2.38] Abdel-Hamid, Nagwa I., Mona F. El-Azab, and Yasser M. Moustafa. "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." Naunyn-Schmiedeberg's Archives of Pharmacology (2017): 1-17. IHC-P ; Rat. PubMed:28070612 [IF=2.37] Liu, Jun-Song, et al. "β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation." World J Gastroenterol 21.34 (2015): 9945-9956. WB ; Human. PubMed:26379399 [IF=2.33] Yang, Juan, Guiyuan Li, and Keqiang Zhang. "Pro-survival effects by NF-κB, Akt and ERK (1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer." Biomedicine & Pharmacotherapy 84 (2016): 1078-1087. WB ; Human. PubMed:27780136 [IF=2.31] Dong, Liwei, et al. "Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1." OncoTargets and Therapy 8 (2015): 3649. Human. PubMed:26677335 [IF=2.27] Li, M., et al. ʺmiR‐34c works downstream of p53 leading to dairy goat male germline stem‐cell (mGSCs) apoptosis.ʺ Cell Proliferation 46.2 (2013): 223-231. WB ; Goat. PubMed:23510477 [IF=2.15] Tang, Xi-Lan, et al. "The Cardioprotective Effect of Protocatechuic Acid on Myocardial Ischemia/Reperfusion Injury." Journal of Pharmacological Sciences 125.2 (2014): 176-183. WB ; Rat. PubMed:24942213 [IF=2.13] Cetintas, Vildan Bozok, et al. "Effects of flavopiridol on critical regulation pathways of CD133high/CD44high lung cancer stem cells." Medicine 95.43 (2016): e5150. IF(ICC) ; Mouse. PubMed:27787370 [IF=2.1] Zhang, Beiru, et al. "The Toxicity Mechanisms of Action of Aβ25–35 in Isolated Rat Cardiac Myocytes." Molecules 19.8 (2014): 12242-12257. WB ; Rat. PubMed:25123188 [IF=2.1] Hu, Hanhua, et al. "Drug-induced apoptosis of Echinococcus granulosus protoscoleces." Parasitology research 109.2 (2011): 453-459. IHC-P ; Others. PubMed:21365454 [IF=2.088] Wu LY, et al. Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-B Pathway. Behav Neurol. 2018 Jun 3;2018:1960106. WB ; Rat. PubMed:29971136 [IF=2.03] Aksu, Ilkay, et al. "Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes." Neuroscience Letters (2012). Rat. PubMed:23123774 [IF=1.949] Li Q et al. The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway.(2018) Lasers Med Sci. Sep 15 WB ; mouse. PubMed:30218348 [IF=1.894] An N et al. Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias.(2018) Med Sci Monit. WB ; Rat . PubMed:30538214 [IF=1.871] Huang XW et al. Scutellarein suppresses Aβ‑induced memory impairment via inhibition of the NF‑κB pathway in vivo and in vitro. Oncol Lett. 2019 Jun;17(6):5581-5589. WB ; Rat. PubMed:31186780 [IF=1.85] Li, Mingzhao, et al. ʺExpression of miR‐34c in response to overexpression of Boule and Stra8 in dairy goat male germ line stem cells (mGSCs).ʺ Cell Biochemistry and Function (2013). Goat. PubMed:23508548 [IF=1.83] KASSAYOVÁ, MONIKA, et al. "Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer." Anticancer Research 36.6 (2016): 2719-2728. IHC-P ; Rat. PubMed:27272781 [IF=1.77] Sun et al. Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells. (2016) Neural.Regen.Re. 11:1159-64 IF(ICC) ; Human. PubMed:27630703 [IF=1.77] Sun et al. Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells. (2016) Neural.Regen.Re. 11:1159-64 IF(ICC) ; Human. PubMed:27630703 [IF=1.72] Zhao, Jun, et al. "The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo." Experimental and Toxicologic Pathology (2016). ELISA ; Human. PubMed:27344612 [IF=1.701] Kosutova P et al. Reduction of Lung Inflammation, Oxidative Stress and Apoptosis by the PDE4 Inhibitor Roflumilast in Experimental Model of Acute Lung Injury. Physiol Res. 2018 Dec 31;67(Supplementum 4):S645-S654. IHC ; Rabbit. PubMed:30607971 [IF=1.69] Song et al. Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways. (2015) Mol.Med.Re. 12:7615-22 WB ; Human. PubMed:26459718 [IF=1.64] Kosutova, P., et al. "Intravenous dexamethasone attenuated inflammation and influenced apoptosis of lung cells in an experimental model of acute lung injury." Physiological research 65.Supplementum 5 (2016): S663. IHC-P ; Rabbit. PubMed:28006948 [IF=1.616] Wang YY et al. GABA regulates the proliferation and apoptosis of MAC-T cells through the LPS-induced TLR4 signaling pathway.Res Vet Sci. 2018 Jun;118:395-402. WB ; Bovine. PubMed:29684816 [IF=1.56] Qu, Zhongyuan, et al. "Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells." Molecular medicine reports 13.2 (2016): 1336-1344. WB ; Human. PubMed:26677104 [IF=1.55] Jia, Jianping, et al. "A preliminary study of the effect of ECRG4 overexpression on the proliferation and apoptosis of human laryngeal cancer cells and the underlying mechanisms." Molecular Medicine Reports. Human. PubMed:26165988 [IF=1.55] Song, Guijun, et al. "Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimers disease via mammalian target of rapamycin-dependent and-independent pathways." Molecular Medicine Reports. WB ; Human. PubMed:not posted yet [IF=1.55] Ding, Qing, et al. "8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells." Molecular medicine reports 12.4 (2015): 5100-5108. WB ; Human. PubMed:26151347 [IF=1.55] Han, Ning, et al. "Agmatine protects Müller cells from high‑concentration glucose‑induced cell damage via N‑methyl‑D‑aspartic acid receptor inhibition." Molecular medicine reports 12.1 (2015): 1098-1106. WB ; Rat. PubMed:25816073 [IF=1.55] Yang, Jinjiang, Ying Lu, and Ai Guo. "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." Molecular Medicine Reports 14.5 (2016): 4075-4082. WB ; Rat. PubMed:27665780 [IF=1.51] Sun, Y‐L., et al. "Relationship between apoptosis and proliferation in granulosa and theca cells of cystic follicles in sows." Reproduction in domestic animals 47.4 (2012): 601-608. IHC-P ; Pig. PubMed:22023076 [IF=1.48] Liu, Yong‑Chao, et al. "RNAi-mediated gene silencing of vascular endothelial growth factor C suppresses growth and induces apoptosis in mouse breast cancer in vitro and in vivo." Oncology Letters. (2016) WB ; Mouse. PubMed:27666771 [IF=1.41] Song et al. Effects of HSYA on the proliferation and apoptosis of MSCs exposed to hypoxic and serum deprivation conditions. (2018) Exp.Ther.Med. 15:5251-5260 WB ; Rat. PubMed:29904409 [IF=1.243] Li W et al. Gallic acid caused cultured mice TM4 Sertoli cells apoptosis and necrosis. (2018) Asian-australas. J. Anim. Sci. Oct 26. WB ; Mouse. PubMed:30381745 [IF=1.14] Wang, J., et al. "Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway." Brazilian Journal of Medical and Biological Research (2014): 000-000. WB ; Mouse. PubMed:25517918 [IF=1.06] Zhang, Xiaolin, and Hao Yu. "Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression (Supplement 2016)." Iranian Journal of Pharmaceutical Research (2016). WB ; Rat. PubMed:27642320 [IF=.87] Ochigbo, Grace Onyeche, et al. "Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis." Journal of Ayurveda and Integrative Medicine (2017). Rat. PubMed:28256303 [IF=0] Li et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. (2015) J.Exp.Clin.Cancer.Res. 34:137 WB ; Human. PubMed:26538209 [IF=0] Wang, Yu, et al. "Tanshinone II A Relieves Adriamycin-induced Myocardial Injury in Rat Model." International Journal of Chemistry 8.1 (2016): 40. WB ; Rat. PubMed:10.5539/ijc.v8n1p40 [IF=0] Petty, Howard R. "NANOPARTICLE THERAPY IN CANCER." U.S. Patent No. 20,150,335,744. 26 Nov. 2015. IF(ICC) ; PubMed:1111 [IF=0] Xia et al. Reversion of p-glycoprotein-mediated multidrug resistance in human leukemic cell line by diallyl trisulfide. (2012) Evid.Based.Complement.Alternat.Me. 2012:719805 WB ; Human. PubMed:22919419 [IF=0] Tang et al. The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury. (2013) Evid.Based.Complement.Alternat.Me. 2013:820695 WB ; Rat. PubMed:23737849 [IF=0] Zhou et al. Suppression of E. multilocularis hydatid cysts after ionizing radiation exposure. (2013) PLoS.Negl.Trop.Di. 7:e2518 WB ; Mouse. PubMed:24205427 [IF=0] Zhong et al. MicroRNA-200a inhibits epithelial-mesenchymal transition in human hepatocellular carcinoma cell line. (2015) Int.J.Clin.Exp.Patho. 8:9922-31 WB ; Human. PubMed:26617701 [IF=0] Pang and Fan Cytotoxic effect and possible mechanisms of Tetracaine on human corneal epithelial cells in vitro. (2016) Int.J.Ophthalmo. 9:497-504 ELISA ; Human. PubMed:27162719 [IF=0] Li X et al. High level expression of ISG12 (1) promotes cell apoptosis via mitochondrial-dependent pathway and so as to hinder Newcastle disease virus replication.(2019)Vet Microbiol. Jan;228:147-156. WB ; Chicken. PubMed:30593361 [IF=.181] Wang S et al. Insulin-like growth factor-1 inhibits the expression of autophagic ID1 in cerebrovascular endothelial cells. Int J Clin Exp Med 2019;12(8):10486-10493. WB ; Human. PubMed:ISSN:1940-5901/IJCEM0091146 [IF=0] Chen S et al. Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats. J Agric Food Chem. 2019 Mar 20;67(11):3140-3149. WB ; Rat. PubMed:30813721 研究领域肿瘤细胞生物神经生物学信号转导细胞凋亡 Alzheimer's 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2μg/Test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.分子量28kDa细胞定位细胞浆性状Liquid浓度1mg/ml免疫原KLH conjugated synthetic peptide derived from human caspase-3 p17 subunit:1-100/277 亚型IgG纯化方法affinity purified by Protein A储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed 产品介绍The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.Reacts with Caspase-3 subunit p17 and precursor.Function:Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.Subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce.Subcellular Location:Cytoplasm.Tissue Specificity:Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.Post-translational modifications:Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.Similarity:Belongs to the peptidase C14A family.SWISS:P42574Gene ID:836Database links:Entrez Gene: 836 HumanEntrez Gene: 12367 MouseEntrez Gene: 397244 PigEntrez Gene: 100008840 RabbitEntrez Gene: 25402 RatOmim: 600636 HumanSwissProt: P42574 HumanSwissProt: P70677 MouseSwissProt: Q95ND5 PigSwissProt: Q8MJC3 RabbitSwissProt: P55213 RatUnigene: 141125 HumanUnigene: 34405 MouseUnigene: 10562 RatImportant Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.Caspase3广泛分布于各种不同类型的细胞中，是Caspase家族中最重要的凋亡执行者之一，激活的Caspase-3能使许多与细胞结构、细胞周期及DNA修复等相关蛋白或激酶失活，从而使细胞凋亡.产品图片Sample:Lane 1: Spleen (Mouse) Lysate at 40 ugLane 2: Lung (Mouse) Lysate at 40 ugLane 3: Lymph node (Mouse) Lysate at 40 ugLane 4: Cerebrum (Mouse) Lysate at 40 ugLane 5: NIH/3T3 (Mouse) Cell Lysate at 30 ugLane 6: Spleen (Rat) Lysate at 40 ugLane 7: Lung (Rat) Lysate at 40 ugLane 8: Lymph node (Rat) Lysate at 40 ugLane 9: Cerebrum (Rat) Lysate at 40 ugLane 10: Hela (Human) Cell Lysate at 30 ugPrimary: Anti-Caspase-3 (bs-0081R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 35 kDObserved band size: 37 kDSample:Lane 1: Raji (Human) Cell Lysate at 30 ugLane 2: NIH/3T3 (Mouse) Cell Lysate at 30 ugLane 3: Lung (Mouse) Lysate at 40 ugLane 4: Lung (Rat) Lysate at 40 ugPrimary: Anti-Caspase-3 (bs-0081R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 35 kDObserved band size: 37 kDSample:Kidney (Mouse) Lysate at 40 ugPrimary: Anti-Caspase-3 (bs-0081R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 28 kDObserved band size: 17 kDSample:Liver (Mouse) Lysate at 40 ugPrimary: Anti-Caspase-3 (bs-0081R) at 1/500 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 28 kDObserved band size: 28 kDSample: Raji Cell lysate;Primary: Anti-Caspase-3 (bs-0081R) at 1:300;Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000;Predicted band size: 17/28 kDObserved band size: 26 kDSample:Liver(Sheep)Lysate at 40 ugPrimary: Anti-Caspase-3(bs-0081R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 28kDObserved band size: 30kDSample:Lung(Mouse) Lysate at 40 ugHela(Human) Cell Lysate at 30 ugNIH/3T3(Mouse) Cell Lysate at 30 ugPrimary: Anti-Caspase-3 (bs-0081R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 35/29/19/17 kDObserved band size: 38 kDProtein:Lung(Mouse) lysate at 30ug;Primary: Anti-caspase-3 (bs-0081R) at 1:300 dilution;Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1: 5000;Predicted band size : 17/28 kDObserved band size : 28 kDTissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;Incubation: Anti-Caspase-3 Polyclonal Antibody, Unconjugated(bs-0081R) 1:200, overnight at 4癈, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) stainingTissue/cell: rabbit pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;Incubation: Anti-Caspase-3 Polyclonal Antibody, Unconjugated(bs-0081R) 1:300, overnight at 4癈, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) stainingTissue/cell: NIH/3T3 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (Caspase-3) polyclonal Antibody, Unconjugated (bs-0081R) 1:100, 90 minutes at 37°C; followed by a FITC conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.The figure annotation:The blue histogram is unstained cells. The Orange histogram is cells stained with Rabbit IgG/FITC (bs-0295P-FITC).The green histogram is cells stained with Rabbit Anti-Caspase-3/FITC Conjugated antibody (bs-0081R-FITC).ControlsPositive control: HepG 2 cellsIsotype control: Cell lines treated with Rabbit IgG/FITC (bs-0295P-FITC) instead of the primary antibody to confirm that primary antibody binding is specific. 2μg in 1 00μL1 X PBS containing 0.5% BSA.The figure annotation:The blue histogram is unstained cells.The Orange histogram is cells stained with Rabbit IgG/FITC (bs-0295P-FITC).The green histogram is cells stained with Rabbit Anti-Caspase-3/FITC Conjugated antibody (bs-0081R-FITC).ControlsPositive control: A549 cellsIsotype control: Cell lines treated with Rabbit IgG/FITC(bs-0295P-FITC) instead of the primary antibody to confirm that primary antibody binding is specific. 3μg in 1 00 μL 1 X PBS containing 0.5% BSA.Blank control:Mouse spleen.Primary Antibody (green line): Rabbit Anti-Caspase-3 antibody (bs-0081R)Dilution: 2μg /10^6 cells;Isotype Control Antibody (orange line): Rabbit IgG .Secondary Antibody : Goat anti-rabbit IgG-AF488Dilution: 1μg /test.ProtocolThe cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 0.1% PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

产品编号bs-0061R英文名称beta-Actin (Loading Control)中文名称β-肌动蛋白/β-Actin（内参）抗体别名Beta Actin; beta-Actin; ACTB; Actin cytoplasmic 1; Actin, beta; Beta actin; beta cytoskeletal actin;A X actin like protein; ACTB; Actin cytoplasmic 1; alpha sarcomeric Actin; Actx; Beta cytoskeletal actin; Melanoma X actin; PS1TP5BP1; ACTB_HUMAN. Specific References (445) | bs-0061R has been referenced in 445 publications.[IF=11.48] Lan, Feng, et al. "Forkhead box protein 3 in human nasal polyp regulatory T cells is regulated by the protein suppressor of cytokine signaling 3." Journal of Allergy and Clinical Immunology 132.6 (2013): 1314-1321. WB ; Human. PubMed:23910692[IF=11.33] Leclercq, Sophie, et al. "Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior." Nature Communications 8 (2017): 15062. WB ; Mouse. PubMed:28375200[IF=9.13] Yoshino et al. PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma. (2017) Cancer.Res. 77:6321-6329 WB ; human. PubMed:28951458[IF=8.032] Matsui H et al. Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri. Cell Rep. 2019 Feb 12;26(7):1727-1733.e6. WB ; Fish. PubMed:30759385[IF=7.82] Han, Jianfeng, et al. "Cationic Bovine Serum Albumin Based Self‐Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer." Small 10.3 (2014): 524-535. WB ; Mouse. PubMed:24106138[IF=7.6] Teng, I., et al. "Phospholipid-functionalized mesoporous silica nanocarriers for selective photodynamic therapy of cancer." Biomaterials (2013). WB ; Mouse. PubMed:23810081[IF=7.6] Xiang, Bai, et al. "PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer." Biomaterials (2013). WB ; Human. PubMed:23777916[IF=6.941] Yang P et al. Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway. (2018) Cancer Letters. Dec 1;438:76-85. WB ; Mouse. PubMed:30213558[IF=6.41] Long, Yan-Min, et al. "Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction." Nanotoxicology (2015): 1-11. WB ; PubMed:26399585[IF=6.36] Yoshino, Hirofumi, et al. "microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma." Oncotarget. WB ; Human. PubMed:28152509[IF=6.34] Li, Xiaoxia, et al. "AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells." Arteriosclerosis, thrombosis, and vascular biology 28.10 (2008): 1789-1795. WB ; Human. PubMed:18599796[IF=6.217] Wang L et al. Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways. J Exp Clin Cancer Res. 2019 Feb 21;38(1):93. WB ; Human. PubMed:30791957[IF=6.02] Zhang J et al. Disruption of the Superoxide Anions-Mitophagy Regulation Axis Mediates Copper Oxide Nanoparticles-Induced Vascular Endothelial Cell Death. Free Radic. Biol. Med. Sep 21;129:268-278 WB ; Human. PubMed:30248444[IF=6.02] Bodas M et al. Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis.(2018) Free Radic Biol Med.131:81-97. WB ; Human. PubMed:30500419[IF=5.922] Sakaguchi et al. Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer. (2017) Br.J.Cancer. 116:1077-1087 WB ; Human. PubMed:28324890[IF=5.595] Liu T et al. MicroRNA-493 targets STMN-1 and promotes hypoxia-induced epithelial cell cycle arrest in G/M and renal fibrosis. (2018) FASEB J. Sep 05 WB ; Mouse. PubMed:30183377[IF=5.595] Li J et al. Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defectregeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation. FASEB J. 2019 Feb 18:fj201802187R. WB ; Mouse. PubMed:30776318[IF=5.58] Cai, Xingcai, et al. "Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways."Scientific Reports 6 (2016): 26802. WB ; Mouse. PubMed:27225984[IF=5.58] Zhou, Xiaoqiao, et al. "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." Scientific Reports6 (2016): 27876. WB ; Pig. PubMed:27296244[IF=5.57] Sakaguchi, Takashi, et al. "Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer." British journal of cancer 116.8 (2017): 1077. WB ; Human. PubMed:28324890[IF=5.54] Yoshihara et al. Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. (2018) PLoS.Genet. 14:e1007545 WB ; Mouse. PubMed:30114188[IF=5.511] Voogdt et al. Evolutionary Regression and Species-Specific Codon Usage of TLR15. (2018) Front.Immunol. 9:2626 WB ; Human. PubMed:30483270[IF=5.5] Cai, Xingcai, et al. "α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway." The FASEB Journal (2017): fj-201700670R. WB ; PubMed:28939592[IF=5.5] Zhang et al. Cardiac Contractility Modulation Attenuate Myocardial Fibrosis by Inhibiting TGF-β1/Smad3 Signaling Pathway in a Rabbit Model of Chronic Heart Failure. (2016) Cell.Physiol.Biochem. 39:294-307 WB ; Rabbit. PubMed:27344462[IF=5.5] Deng G et al. miR-136-5p Regulates the Inflammatory Response by Targeting the IKKβ/NF-κB/A20 Pathway After Spinal Cord Injury.(2018) Cell Physiol Biochem;50:512-524 WB ; Rat . PubMed:30308489[IF=5.48] Wu, Bin, et al. "Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2017). WB ; Mouse. PubMed:28634116[IF=5.41] Yan, Wenjun, et al. "SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain." Journal of Cerebral Blood Flow & Metabolism 33.3 (2013): 396-406. Rat. PubMed:23299244[IF=5.253] Liu,et al.Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment.(2018) Angiogenesis. 21:237-249. WB ; Human. PubMed:29299781[IF=5.23] Zhuang, Pengwei, et al. "cAMP-PKA-CaMKII signaling pathway is involved in aggravated cardiotoxicity during Fuzi and Beimu Combination Treatment of Experimental Pulmonary Hypertension." Scientific Reports 6 (2016): 34903. WB ; Rat. PubMed:27739450[IF=5.21] Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856. WB ; Rabbit. PubMed:22422340[IF=5.17] Xu et al. Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. (2015) Oncotarge. 6:26161-76 WB ; Human. PubMed:26317652[IF=5.17] Sun et al. YAP1 enhances cell proliferation, migration, and invasion of gastric cancer in vitro and in vivo. (2016) Oncotarge. 7:81062-81076 WB ; Human. PubMed:27835600[IF=5.17] Li et al. Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma. (2015) Oncotarge. 6:1544-55 WB ; Human. PubMed:25575816[IF=5.17] Xu et al. Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. (2015) Oncotarge. 6:26161-76 WB ; Human. PubMed:26317652[IF=5.17] Sun et al. YAP1 enhances cell proliferation, migration, and invasion of gastric cancer in vitro and in vivo. (2016) Oncotarge. 7:81062-81076 WB ; Human. PubMed:27835600[IF=5.168] Wang,et al.Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri.(2018) Oncotarget. 9:14882-14894. WB ; Fish. PubMed:29599913[IF=5.14] Xu, Xiaofeng, et al. "Preferential Heme Oxygenase-1 Activation in Striatal Astrocytes Antagonizes Dopaminergic Neuron Degeneration in MPTP-Intoxicated Mice." Molecular Neurobiology (2015): 1-10. WB ; Mouse. PubMed:26385576[IF=5.14] Xu, Xiaofeng, et al. "Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan."Molecular Neurobiology (2016): 1-9. WB ; PubMed:26887382[IF=5.13] Liu, Qun, et al. "6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α." Molecular cancer 12.1 (2013): 135. WB ; Human. PubMed:24215632[IF=5.1] Ling, Feng, et al. "Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300." Oncotarget 8.42 (2017): 72773. WB ; PubMed:29069825[IF=5.07] Song, Dongmei, et al. "Ulinastatin Activates Heme Oxygenase‐1 Antioxidant Pathway and Attenuates Allergic Inflammation." British Journal of Pharmacology (2014). WB ; Mouse. PubMed:24835359[IF=5] Tamburrino et al. The CatSper calcium channel in human sperm: relation with motility and involvement in progesterone-induced acrosome reaction. (2014) Hum.Reprod. 29:418-28 other ; Human. PubMed:24430778[IF=5] Li, Bo, et al. "Long noncoding RNA CCAT1 functions as a ceRNA to antagonize the effect of miR-410 on the down-regulation of ITPKB in human HCT-116 and HCT-8 cells." Oncotarget 8.54 (2017): 92855. WB ; Human. PubMed:29190961[IF=4.87] Liu H et al. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in MPTP‐induced Parkinson's disease in mice. J Neurochem. 2019 Aug 23. WB ; Mouse. PubMed:31442326[IF=4.784] Wan B et al. Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction. Int J Biol Macromol. 2019 Jul 5;138:198-206. WB ; Monkey. PubMed:31284005[IF=4.653] Wang C et al. Human Milk Oligosaccharides Protect Against Necrotizing Enterocolitis by Inhibiting Intestinal Damage Via Increasing the Proliferation of Crypt Cells. Mol Nutr Food Res. 2019 Jun 17:e1900262. WB ; Mouse. PubMed:31207104[IF=4.652] Yang et al. SIRT1 regulates CD40 expression induced by TNF-α via NF-ĸB pathway in endothelial cells. (2012) Cell.Physiol.Bioche. 30:1287-98 WB ; Human. PubMed:23075766[IF=4.609] Shen et al. Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model. (2017) J.Neurochem. 140:799-813 WB ; Rat. PubMed:27987215[IF=4.57] Tsuboi, Koichiro, et al. "Autophagy protects against colitis by the maintenance of normal gut microflora and secretion of mucus." Journal of Biological Chemistry 290.33 (2015): 20511-20526. WB ; Mouse. PubMed:26149685[IF=4.56] Xia et al. Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish. (2017) Genetics. WB ; Zebrafish. PubMed:29196300[IF=4.56] Wu et al. Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. (2016) Immunol.Cell.Bio. 94:285-92 WB ; Human. PubMed:26471241[IF=4.53] Zheng D et al. Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy. FEBS J. 2019 Feb 12. WB ; Mouse. PubMed:30748104[IF=4.5] Jiao, Zhang Jiao, et al. "MicroRNA-1285 regulates 17β-estradiol-inhibited immature boar Sertoli cell proliferation via adenosine monophosphate-activated protein kinase activation." Endocrinology (2015): en-2014. WB ; PubMed:26287402[IF=4.473] Wu et al. Calcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway. (2016) Immunol.Cell.Bio. 94:285-92 WB ; Human. PubMed:26471241[IF=4.41] Zeng, Xiaoyun, et al. "A Newly Synthesized Sinapic Acid Derivative Inhibits Endothelial Activation In Vitro and In Vivo." Molecular Pharmacology (2013). WB ; Human. PubMed:23470287[IF=4.38] Zhu, Yuxuan, et al. "Antioxidant and Antiapoptotic Effects of 1, 1′-(Biphenyl-4, 4′-diyl)-bis (3-(dimethylamino)-propan-1-one) on Protecting PC12 Cells from Aβ-Induced Injury." Molecular pharmaceutics 11.2 (2013): 428-435. WB ; Rat. PubMed:24350730[IF=4.379] Pan et al. Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis. (2018) Mar.Drugs. 16 WB ; Rabbit. PubMed:29874843[IF=4.302] Song JL et al. Functional role of RRS 1 in breast cancer cell proliferation.(2018) J Cell Mol Med. Dec;22(12):6304-6313. WB ; Human. PubMed:30320499[IF=4.302] Zuo L et al. PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation. J Cell Mol Med. 2019 Apr 2. WB ; Rat. PubMed:30938088[IF=4.263] Wu X et al.The role of Ca 2+ in acid-sensing ion channel 1a-mediated chondrocyte pyroptosis in rat adjuvant arthritis.(2018) Lab Invest. WB ; Rat . PubMed:30487596[IF=4.26] Wang, Ye-Jun, et al. "Two oral HBx vaccines delivered by live attenuated Salmonella: Both eliciting effective anti-tumor immunity." Cancer letters 263.1 (2008): 67-76. WB ; PubMed:18226855[IF=4.26] Li, Chengcheng, et al. "Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway." Scientific Reports 7 (2017). WB ; Mouse. PubMed:28725012[IF=4.258] Yang et al. RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. (2011) J.Biol.Che. 286:11865-74 WB ; Human. PubMed:21310960[IF=4.22] Hou, Yiling, et al. "Structure elucidation, proliferation effect on macrophage and its mechanism of a new heteropolysaccharide from Lactarius deliciosus Gray." Carbohydrate Polymers (2016). WB ; Other Species. PubMed:27516315[IF=4.2] Yang, Wucai, et al. "Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes." Scientific Reports 7.1 (2017): 15080. WB ; Bovine. PubMed:29118419[IF=4.181] Ogura et al. Vibrio cholerae Cholix Toxin-Induced HepG2 Cell Death is Enhanced by Tumor Necrosis Factor-Alpha Through ROS and Intracellular Signal-Regulated Kinases. (2017) Toxicol.Sci. 156:455-468 WB ; Mouse. PubMed:28087840[IF=4.13] Fu, Chenglai, et al. "Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae." Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1801.7 (2010): 702-710. WB ; PubMed:20382259[IF=4.122] Zhang et al. Non-thermal plasma treatment improves chicken sperm motility via the regulation of demethylation levels. (2018) Sci.Rep. 8:7576 WB ; Chicken. PubMed:29765100[IF=4.12] Wang et al. Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation. (2016) Sci.Rep. 6:36543 WB ; Human. PubMed:27824118[IF=4.021] Dinesh P et al. Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. Apoptosis. 2019 May 20. WB ; Rat. PubMed:31111379[IF=3.994] Wang Z et al. Effects of exercise-induced fatigue on the morphology of asymmetric synapse and synaptic protein levels in rat striatum. Neurochem Int. 2019 May 27;129:104476. WB ; Rat. PubMed:31145967[IF=3.98] Lu, Naisheng, et al. "Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells." The Journal of Steroid Biochemistry and Molecular Biology (2017). WB ; Pig. PubMed:28602959[IF=3.974] Li S et al. Detection of Aflatoxin adducts as potential markers and the role of curcumin in alleviating AFB1-induced liver damage in chickens.Ecotoxicol Environ Saf. 2019 Jul 30;176:137-145. WB ; Chicken. PubMed:30925330[IF=3.923] Song LL et al. TGF-β and HSP70 profiles during transformation of yak hair follicles from the anagen to catagen stage. J Cell Physiol. 2019 Feb 5. WB ; Yak. PubMed:30723905[IF=3.92] Du, Si‐Qi, et al. "Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats." CNS Neuroscience & Therapeutics (2017). WB ; Rat. PubMed:29110407[IF=3.88] Ogura, Kohei, et al. "Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases." Toxicological Sciences (2017): kfx009. WB ; Mouse. PubMed:28087840[IF=3.87] Hou, Yiling, et al. "Structure elucidation and antitumor activity of a new polysaccharide from Maerkang Tricholoma matsutake." International Journal of Biological Sciences 13.7 (2017): 935-948. WB ; Mouse. PubMed:28808425[IF=3.86] Ommati, Mohammad Mehdi, et al. "Dual effects of sulfasalazine on rat sperm characteristics, spermatogenesis, and steroidogenesis in two experimental models." Toxicology letters (2017). WB ; Rat. PubMed:29197623[IF=3.85] Wu, Yuting, et al. "Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis." Toxicology and Applied Pharmacology 315 (2017): 35-49. WB ; Mouse. PubMed:27939986[IF=3.85] Li, Yue, et al. "Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells." Toxicology and Applied Pharmacology. (2017). Human. PubMed:28130038[IF=3.85] Huang, Huimin, et al. "HMGA2, a driver of inflammation, is associated with hypermethylation in acute liver injury." Toxicology and Applied Pharmacology (2017). WB ; Mouse. PubMed:28502886[IF=3.84] Yin, Di, et al. "Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo." Nanotechnology 24.10 (2013): 105102. WB ; Mouse. PubMed:23425941[IF=3.84] Yin, Di, et al. "Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo." Nanotechnology 24.10 (2013): 105102. WB ; PubMed:23425941[IF=3.84] Chen, Siying, et al. "HDACI regulates the PI3K/Akt signaling pathway to reverse MCF-7/PTX resistance by inhibiting SET." RSC Advances (2016). WB ; Human. PubMed:10.1039/c6ra06423j[IF=3.84] Shen, P. P., et al. "Cortical Spreading Depression (CSD) Preconditioning Mediates Neuroprotection against Ischemic Stroke by Inducing AMP‐activated Protein Kinase‐dependent Autophagy in a Rat Cerebral Ischemic/reperfusion Injury Model." Journal of Neurochemistry (2016). WB ; Rat. PubMed:27987215[IF=3.83] Cheng et al. miR-203 Inhibits Alcohol-Induced Hepatic Steatosis by Targeting Lipin1. (2018) Front.Pharmacol. 9:275 WB ; Mouse. PubMed:29670525[IF=3.817] Zhao et al. Involvement of DNA polymerase β overexpression in the malignant transformation induced by benzo[a]pyrene. (2013) Toxicolog. 309:73-80 WB ; Mouse. PubMed:23652152[IF=3.81] Huang, Yu‐lin, et al. "Spermatogenesis‐associated proteins at different developmental stages of buffalo testicular seminiferous tubules identified by comparative proteomic analysis." Proteomics (2016). WB ; Other Species. PubMed:27173832[IF=3.79] Wang, Xiaoqiu, et al. "Temporal Proteomic Analysis Reveals Defects in Small Intestinal Development of Porcine Fetuses with Intrauterine Growth Restriction." The Journal of Nutritional Biochemistry (2014). WB ; PubMed:24794015[IF=3.79] Fu, Yujie, et al. "Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer." The Journal of Nutritional Biochemistry (2015). WB ; Human. PubMed:26365581[IF=3.786] Shen XF et al. Role of DNA hypomethylation in lateral habenular nucleus is involved in the development of depressive-like behavior in rats.J Affect Disord. 2019 Jun 1;252:373-381. WB ; Rat. PubMed:30999094[IF=3.77] Miao, Xue-Rong, et al. "[EXPRESS] DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1. 2 expression in spinal cord dorsal horn." Molecular Pain 13 (2017): 1744806917740681. WB ; Rat. PubMed:29056068[IF=3.766] Song G et al. Chrysophanol attenuates airway inflammation and remodeling through nuclear factor‐kappa B signaling pathway in asthma. Phytother Res. 2019 Jul 17. WB ; Mouse&Human. PubMed:31313371[IF=3.743] Lu Y et al. Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway. Biomed Pharmacother. 2019 Aug;116:109054. WB ; Mouse. PubMed:31176122[IF=3.74] Yuan, Zuoqing, et al. "Changes on lipid peroxidation, enzymatic activities and gene expression in planarian (Dugesia japonica) following exposure to perfluorooctanoic acid." Ecotoxicology and Environmental Safety 145 (2017): 564-568. WB ; Other Species. PubMed:28800531[IF=3.73] Wang, Wei, et al. "Cynoglossus semilaevis ISG15: A Secreted Cytokine-Like Protein That Stimulates Antiviral Immune Response in a LRGG Motif-Dependent Manner." PLOS ONE 7.9 (2012): e44884. WB ; PubMed:23028660[IF=3.73] Gao, Jin-Hang, et al. "Celecoxib Ameliorates Portal Hypertension of the Cirrhotic Rats through the Dual Inhibitory Effects on the Intrahepatic Fibrosis and Angiogenesis." PLOS ONE 8.7 (2013): e69309. WB ; Rat. PubMed:23922700[IF=3.73] Hou, Cong-Cong, and Wan-Xi Yang. "Acroframosome-Dependent KIFC1 Facilitates Acrosome Formation during Spermatogenesis in the Caridean Shrimp Exopalaemon modestus."?PLOS ONE?8.9 (2013): e76065. WB ; PubMed:24098763[IF=3.7] Wu, Yuting, et al. "Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion."Toxicology and Applied Pharmacology (2015). WB ; Mouse. PubMed:26435214[IF=3.7] Ma, Yanqin, et al. "Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells." Chemosphere 167 (2017): 454-461. WB ; Human. PubMed:27750169[IF=3.687] Pang et al. Inhibitory Effect of Methotrexate on Rheumatoid Arthritis Inflammation and Comprehensive Metabolomics Analysis Using Ultra-Performance Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry (UPLC-Q/TOF-MS). (2018) Int.J.Mol.Sci. 19 WB ; Rat. PubMed:30249062[IF=3.68] Wang et al. Abortive infection of snakehead fish vesiculovirus in ZF4 cells was associated with the RLRs pathway activation by viral replicative intermediates. (2015) Int.J.Mol.Sci. 16:6235-50 Control,WB ; Zebrafish. PubMed:25794284[IF=3.68] Li et al. Berberine Alleviates Olanzapine-Induced Adipogenesis via the AMPKα-SREBP Pathway in 3T3-L1 Cells. (2016) Int.J.Mol.Sci. 17 WB ; Mouse. PubMed:27834848[IF=3.68] He, Mu-Dan, et al. "Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis (2015). WB ; PubMed:26318124[IF=3.68] Zhong et al. High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10. (2014) Microb.Cell.Fac. 13:163 WB ; PubMed:25425395[IF=3.64] Shi, Ran-ran, et al. "The immunogenicity of a novel cytotoxic T lymphocyte epitope from tumor antigen PL2L60 could be enhanced by 4-chlorophenylalanine substitution at position 1."?Cancer Immunology, Immunotherapy?(2013): 1-10. WB ; Human. PubMed:24077852[IF=3.62] Wang, Peng, et al. "Trans-generational enhancement of C-type lysozyme level in eggs of zebrafish by dietary β-glucan." Developmental & Comparative Immunology (2017). other ; PubMed:28408333[IF=3.616] Sun X et al. Methamphetamine produces cardiac damage and apoptosis by decreasing melusin.Toxicol Appl Pharmacol. 2019 Mar 20. WB ; Rat. PubMed:30904475[IF=3.61] Wang, Li, et al. "Silencing stem cell factor attenuates stemness and inhibits migration of cancer stem cells derived from Lewis lung carcinoma cells."Tumor Biology (2015): 1-15. WB ; Mouse. PubMed:26666817[IF=3.609] Yan et al. Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells. (2015) J.Cance. 6:151-9 WB ; Human. PubMed:25561980[IF=3.585] Feng Y et al. ATPR-induced differentiation and G0/G1 phase arrest in acute promyelocytic leukemia by repressing EBP50/NCF1 complex to promote the production of ROS. Toxicol Appl Pharmacol. 2019 Jun 27;379:114638. WB ; Mouse&Human. PubMed:31254567[IF=3.571] Tian M et al. Dietary Branched-Chain Amino Acids Regulate Food Intake Partly through Intestinal and Hypothalamic Amino Acid Receptors in Piglets. J Agric Food Chem. 2019 Jun 19;67(24):6809-6818. WB ; Piglet. PubMed:31134808[IF=3.571] Huang H et al. AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes. Metallomics. 2019 Jun 26. WB ; Human. PubMed:31241124[IF=3.562] Liu YJ et al. The expression of three opsin genes and phototactic behavior of Spodoptera exigua (Lepidoptera: Noctuidae): evidence for visual function of opsin in phototaxis.Insect Biochem Mol Biol. 2018 May;96:27-35. WB ; Moth. PubMed:29625217[IF=3.55] Guo, Hong-Feng, et al. "Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications." Colloids and Surfaces B: Biointerfaces (2012). WB ; Mouse. PubMed:22503631[IF=3.547] Zhang LB et al. Pregnancy exposure to carbon black nanoparticles exacerbates bleomycin-induced lung fibrosis in offspring via disrupting LKB1-AMPK-ULK1 axis-mediated autophagy. Toxicology, 2019, 152244. WB ; Mouse. PubMed:doi:10.1016/j.tox.2019.152244[IF=3.536] Zhang,et al.Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model.(2018) Journal of Vascular Surgery. :. IF(IHC-F) ; Rat. PubMed:29395422[IF=3.53] Wang, Bingxiang, et al. "7, 8-Dihydroxyflavone Protects an Endothelial Cell Line from H 2 O 2 Damage." PloS one 10.8 (2015): e0135345. WB ; Human. PubMed:26266800[IF=3.53] Zhou, Wenjing, et al. "Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells." Cell Cycle 16.1 (2017): 73-81. WB ; PubMed:27841696[IF=3.47] Wang JX et al. Lactoferrin stimulates the expression of vitamin D receptor in vitamin D deficient mice. Journal of Functional Foods 55 (2019) 48–56. WB ; Mouse. PubMed:10.1016/j.jff.2019.02.012[IF=3.457] Hu J et al. Silencing ZAP70 prevents HSP65-induced reverse cholesterol transport and NF-κB activation in T cells. Biomedicine & Pharmacotherapy,2018 102, 271–277. WB ; Human. PubMed:10.1016/j.biopha.2018.03.082[IF=3.457] G V et al. Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and Aβ expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer's disease: A pilot study.Biomed Pharmacother. 2018 Aug;104:211-222. WB ; Human. PubMed:29775888[IF=3.457] Cui L et al. Signaling pathways involved in the expression of SZNF and the target genes binding with SZNF related to cyadox.(2018) Biomed Pharmacother. 2018 Dec;108:1879-1893. WB ; swine. PubMed:30453449[IF=3.448] Han Z et al. MicroRNA-99a-5p alleviates atherosclerosis via regulating Homeobox A1. Life Sci. 2019 Jul 17:116664. WB ; Mouse&Human. PubMed:31325426[IF=3.448] Liu X et al. Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles. Life Sci. 2019 Sep 15;233:116741. WB ; Mouse. PubMed:31398419[IF=3.448] Yue P et al. Down-regulation of taurine-up-regulated gene 1 attenuates inflammation by sponging miR-9-5p via targeting NF-κB1/p50 in multiple sclerosis. Life Sci. 2019 Sep 15;233:116731. WB ; Mouse. PubMed:31394128[IF=3.44] Li B et al.Effect of Melatonin on Attenuating the Isoflurane-Induced Oxidative Damage is Related to PKCα/Nrf2 Signaling Pathway in Developing Rats.(2018) Brain Res Bull.143:9-18. WB ; Rat. PubMed:30278199[IF=3.44] Zhang X et al.Neuroprotective effects of matrix metalloproteinases in cerebral ischemic rats by promoting activation and migration of astrocytes and microglia.(2018) Brain Res Bull. Nov 13. WB ; Rat. PubMed:30445183[IF=3.42] Xu, R., et al. "Secretoneurin Induces Airway Mucus Hypersecretion by Enhancing the Binding of EGF to NRP1." Cellular Physiology and Biochemistry 33.2 (2014): 446-456. WB ; Human. PubMed:24556756[IF=3.42] Li, Mei, et al. "Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application." Materials Science and Engineering: C (2016). WB ; Mouse. PubMed:28183618[IF=3.414] Tang Q et al. Aqueous extract from You-Gui-Yin ameliorates cognitive impairment of chronic renal failure micethrough targeting hippocampal CaMKIIα/CREB/BDNF and EPO/EPOR pathways. J Ethnopharmacol. 2019 Jul 15;239:111925. WB ; Mouse. PubMed:31055001[IF=3.414] Li X et al. Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. In loperamide-induced rats. J Ethnopharmacol. 2019 Aug 10;240:111961. WB ; Rat. PubMed:31102614[IF=3.4] Ruan Z, Liu S, Zhou Y, Mi S, Liu G, Wu X, et al. (2014) Chlorogenic Acid Decreases Intestinal Permeability and Increases Expression of Intestinal Tight Junction Proteins in Weaned Rats Challenged with LPS. PLoS ONE 9(6): e97815 WB ; Rat. PubMed:24887396[IF=3.392] Han L et al. Beneficial Effects of Potentilla discolor Bunge Water Extract on Inflammatory Cytokines Release and Gut Microbiota in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice.Nutrients. 2019 Mar 20;11(3). WB ; Mouse. PubMed:30897784[IF=3.39] Li, Yanhui, et al. "Role of the Lateral Habenula in Pain-Associated Depression." Frontiers in Behavioral Neuroscience 11 (2017): 31. WB ; Rat. PubMed:28270756[IF=3.386] Zhang et al. Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver. (2011) PPAR.Res. 2011:164925 WB ; Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Bee, Fish, Guinea Pig, Hamster, Goat, Cat, mt,op. PubMed:22190905[IF=3.386] Zhang et al. Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver. (2011) PPAR.Res. 2011:164925 WB ; Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Bee, Fish, Guinea Pig, Hamster, Goat, Cat, mt,op. PubMed:22190905[IF=3.38] Sun, Cheng, et al. "Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions." NeuroToxicology (2015). WB ; PubMed:26702581[IF=3.374] Feng S et al. Development of a reverse genetics system for snakehead vesiculovirus (SHVV). (2018) Virology. Oct 15;526:32-37. WB ; PubMed:30336336[IF=3.345] Lu et al. Marine cyclotripeptide X-13 promotes angiogenesis in zebrafish and human endothelial cells via PI3K/Akt/eNOS signaling pathways. (2012) Mar.Drug. 10:1307-20 WB ; Human. PubMed:22822374[IF=3.333] Osako Y et al. Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2.Int J Oncol. 2019 May;54(5):1759-1770. WB ; Human. PubMed:30816432[IF=3.303] Niu,et al.Aspergillus fumigatus Increased PAR-2 Expression and Elevated Proinflammatory Cytokines Expression Through the Pathway of PAR-2/ERK1/2 in Cornea.(2018) Investigative Ophthalmology & Visual Science. 59:166-175. WB ; Mouse. PubMed:29332129[IF=3.298] HLA-A2-Restricted Epitopes Identified from MTA1 Could Elicit Antigen-Specific Cytotoxic T Lymphocyte Response Y Wu WB ; Human. PubMed:30596107[IF=3.28] Li, Bing-Hua, et al. "Polypeptide from Chlamys farreri inhibits UVB-induced HaCaT cells apoptosis via inhibition CD95 pathway and reactive oxygen species." Free radical research 41.11 (2007): 1224-1232. WB ; Human. PubMed:17907002[IF=3.26] Chen, Chuanxiang, et al. "Role of PUMA in methamphetamine-induced neuronal apoptosis." Toxicology letters 240.1 (2016): 149-160. WB ; Rat. PubMed:26524635[IF=3.241] Tian M et al. Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an in vitro porcine jejunum model. Food Funct. 2019 Jun 19;10(6):3356-3367. WB ; Piglet. PubMed:31098606[IF=3.241] Wang J et al. Donkey milk oligosaccharides influence growth-related characteristics of intestinal cells and induce growth arrest via G2/M by P38 pathway in HT-29 cell. Food Funct. 2019 Jul 18. WB ; Human. PubMed:31318010[IF=3.241] Luo P et al. Ca 2+-Calcineurin-NFAT pathway mediates the effect of thymol on oxidative metabolism and fiber-type switch in skeletal muscle. Food Funct. 2019 Aug 1;10(8):5166-5173. WB ; Mouse. PubMed:31378798[IF=3.24] Chen, Cheng, et al. "The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis." Developmental & Comparative Immunology (2012). WB, IP ; PubMed:23178402[IF=3.24] Qiu, Reng, et al. "Macrophage migration inhibitory factor of Sciaenops ocellatus regulates immune cell trafficking and is involved in pathogen-induced immune response." Developmental & Comparative Immunology (2013). WB ; PubMed:23545285[IF=3.24] Zhang, Jian, Ling Chen, and Li Sun. "SmLMWPTP, a teleost low molecular weight protein tyrosine phosphatase, inhibits the immune response of peripheral blood leukocytes in a manner that depends on the conserved P-loop." Developmental & Comparative Immunology (2013). WB ; PubMed:23500512[IF=3.24] Li, Mo-fei, et al. "First characterization of a teleost Epstein-Barr virus-induced gene 3 (EBI3) reveals a regulatory effect of EBI3 on the innate immune response of peripheral blood leukocytes." Developmental & Comparative Immunology (2013). WB ; Rat. PubMed:23932982[IF=3.24] Chen, Cheng, et al. "The galectin-3-binding protein of Cynoglossus semilaevis is a secreted protein of the innate immune system that binds a wide range of bacteria and is involved in host phagocytosis." Developmental & Comparative Immunology (2012). WB ; PubMed:23178402[IF=3.234] Xia S et al. Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease. (2019) Life Sci.Jan 1;216:75-84. WB ; Rat. PubMed:30428305[IF=3.23] Lin, Xue-Lian, et al. "NPs/NPRs Signaling Pathways May Be Involved in Depression-Induced Loss of Gastric ICC by Decreasing the Production of mSCF." PloS one 11.2 (2016): e0149031. WB ; Rat. PubMed:26862759[IF=3.23] Wang, Xia, et al. "Intermittent food restriction initiated late in life prolongs lifespan and retards the onset of age-related markers in the annual fish Nothobranchius guentheri." Biogerontology 18.3 (2017): 383-396. WB ; Fish. PubMed:28432521[IF=3.202] Zhao L et al. Resensitization of cisplatin resistance ovarian cancer cells to cisplatin through pretreatment with low-dose fraction radiation. Cancer Med. 2019 Apr 2. WB ; Human. PubMed:30941896[IF=3.197] Yuan Q et al. Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin. Journal of Functional Foods, 60, 103435. WB ; Mouse. PubMed:doi:10.1016/j.jff.2019.103435[IF=3.185] Zhang C et al.. MiR-214 inhibits snakehead vesiculovirus (SHVV) replication by targeting host GS. (2018) Fish Shellfish Immunol. 84:299-303. WB ; Striped snakehead. PubMed:30308292[IF=3.185] Li C et al. Glutamine starvation inhibits snakehead vesiculovirus replication via inducing autophagy associated with the disturbance of endogenous glutathione pool. (2018) Fish Shellfish Immunol 86:1044-1052. WB ; striped snakehead. PubMed:30590160[IF=3.18] Yang, Ya’nan, et al. "Vitellogenin2: spermatozoon specificity and immunoprotection in mud crabs." Reproduction 152.3 (2016): 235-243. ELISA ; Other Species. PubMed:27458256[IF=3.17] Liu, Yang, et al. "Amelioration of Stroke-Induced Neurological Deficiency by Lyophilized Powder of Catapol and Puerarin." International Journal of Biological Sciences 10.4 (2014): 448-456. WB ; Mouse. PubMed:24719562[IF=3.166] Zhang et al. Sesamin ameliorates arterial dysfunction in spontaneously hypertensive rats via downregulation of NADPH oxidase subunits and upregulation of eNOS expression. (2013) Acta.Pharmacol.Si. 34:912-20 WB ; Rat. PubMed:23624755[IF=3.166] Bu FT et al. SENP2 alleviates CCl 4 -induced liver fibrosis by promoting activated hepatic stellate cell apoptosis and reversion. Toxicology Letters,2018 289, 86–98. WB ; Mouse. PubMed:10.1016/j.toxlet.2018.03.010 [IF=3.166] Xiao N et al. CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway.Toxicol Lett. 2018 Aug;292:97-107. WB ; Human. PubMed:29705343[IF=3.166] Wang Y et al. ASIC1a promotes high glucose and PDGF-induced hepatic stellate cell activation by inducing autophagy through CaMKKβ/ERK signaling pathway. (2018) Toxicol Lett. (18)31963-5 WB ; Rat. PubMed:30291941[IF=3.166] Guan T et al. Aristolochic acid inhibits Slit2-induced migration and tube formation via inactivation of Robo1/Robo2-NCK1/NCK2 signaling pathway in human umbilical vein. (2019) Toxicol Lett. Jan;300:51-58. WB ; Human. PubMed:30381256[IF=3.166] Yun S et al. Effects of lead exposure on brain glucose metabolism and insulin signaling pathway in the hippocampus of rats. Toxicol Lett. 2019 Aug;310:23-30. WB ; Rat. PubMed:30980912[IF=3.15] Liu, Ping, et al. "Effects of pubertal fenvalerate exposure on testosterone and estradiol synthesis and the expression of androgen and estrogen receptors in the developing brain." Toxicology Letters 201.2 (2011): 181-189. WB ; Mouse. PubMed:21232584[IF=3.15] Yang, Kelin, et al. "Phytol promotes the formation of slow-twitch muscle fibers through PGC-1αmiRNA but not mitochondria oxidation." Journal of Agricultural and Food Chemistry (2017). WB ; Pig. PubMed:28654264[IF=3.14] Yang, Zhaoting, et al. "Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma." Journal of Cancer Research and Clinical Oncology (2016): 1-12. WB ; Human. PubMed:27680978[IF=3.14] Liu, Yaowen, Shuyao Wang, and Rong Zhang. "Composite poly (lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering." International Journal of Biological Macromolecules (2017). WB ; Rat. PubMed:28528953[IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017). WB ; Human. PubMed:28552725[IF=3.12] Ye, R., et al. "Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia." Neuroscience 178 (2011): 169-180. WB ; Rat. PubMed:21219973[IF=3.118] Li YL et al. Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice. (2018) International Immunopharmacology,Nov;64:319-325. WB ; mouse. PubMed:30243067[IF=3.118] Xu J et al.Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-induced experimental inflammatory bowel disease in mice. (2019) Int. Immunopharmacol; Jan;66:28-40. WB ; Mouse. PubMed:30419451[IF=3.118] Su QQ et al.Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity.(2019) Int Immunopharmacol. Jan;66:52-61. WB ; Mouse. PubMed:30445307[IF=3.118] Sun Q et al. Celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1 Int Immunopharmacol. 2019 Feb 21;70:101-109. WB ; Mouse. PubMed:30798158[IF=3.115] Li Y et al. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells.(2018) J Ethnopharmacol 232:47-54. WB ; Human. PubMed:30552993[IF=3.067] Che W et al. Arsenic induces gender difference of estrogen receptor in AECII cells from ICR fetal mice. Toxicol In Vitro. 2019 Apr;56:133-140. WB ; Rat. PubMed:30684567[IF=3.061] Zhou R et al. Clinical features of aflatoxin B1-exposed patients with liver cancer and the molecular mechanism of aflatoxin B1 on liver cancer cells. Environ Toxicol Pharmacol. 2019 Jul 25;71:103225. WB ; Human. PubMed:31376682[IF=3.02] Wang, Yao, et al. "Autophagy induced by snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line." Fish & Shellfish Immunology(2016). WB ; Others. PubMed:27311436[IF=3.02] Ryuzono, Sena, et al. "Suppression of Neu1 sialidase delays the absorption of yolk sac in medaka (Oryzias latipes) accompanied with the accumulation of α2-3 sialo-glycoproteins." Biochimie (2017). WB ; Other Species. PubMed:28111290[IF=3.018] Song et al. Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma. (2016) Int.J.Onco. 49:646-56 WB ; Mouse. PubMed:27277835[IF=2.98] Lin et al. EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells. (2018) Oncol.Rep. 40:29-38 WB ; Human. PubMed:29749533[IF=2.98] Zhang, Heng, et al. "Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood." Journal of Applied Toxicology 30.4 (2010): 369-377. WB ; PubMed:20063364[IF=2.976] Ren et al. Frankincense, pine needle and geranium essential oils suppress tumor progression through the regulation of the AMPK/mTOR pathway in breast cancer. (2018) Oncol.Rep. 39:129-137 WB ; PubMed:29115548[IF=2.976] Chen X et al. Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells.(2019)Oncol Rep. Feb;41(2):765-778. WB ; PubMed:30431140[IF=2.97] Liu, Donghui, et al. "Nonenzymatic glycation of high?\density lipoprotein impairs its anti?\inflammatory effects in innate immunity."iabetes/Metabolism Research and Reviews 28.2 (2012): 186-195..3 WB ; Human. PubMed:21928330[IF=2.97] Sun, Yuan, et al. "Carbon disulfide exposure at peri-implantation disrupts embryo implantation by decreasing integrin ?? 3 expression in the uterine tissue of pregnant mice."Chemico-biological interactions?(2013).x WB ; Mouse. PubMed:24025711[IF=2.96] Yu, Lan-ping, et al. "Characterization of a c-type lysozyme of Scophthalmus maximus: expression, activity, and antibacterial effect." Fish & Shellfish Immunology (2012). WB ; PubMed:23063540[IF=2.959] Wang Q et al. Yak OXGR1 promotes fibroblast proliferation via the PI3K/AKT pathways.(2018) J. Cell. Biochem. WB ; yak. PubMed:30520130[IF=2.959] Yu S et al. Selenoprotein S protects against high glucose-induced vascular endothelial apoptosis through the PKCβII/JNK/Bcl-2 pathway.(2018) J. Cell. Biochem. WB ; Human. PubMed:30485531[IF=2.94] Wang, Yanqin, et al. "Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson’s Disease." PPAR Research 2017 (2017). WB ; Mouse. PubMed:28356907[IF=2.939] Ma X et al. Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability. Inflammation. 2019 Jul 4. WB ; Mouse. PubMed:31273573[IF=2.93] Wang, Yun-Yan, et al. "LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p." Tumor Biology (2016): 1-11. WB ; Human. PubMed:27631965[IF=2.921] Zheng et al. Salvianolic acid A reverses the paclitaxel resistance and inhibits the migration and invasion abilities of human breast cancer cells by inactivating transgelin 2. (2015) Cancer.Biol.The. 16:1407-14 WB ; Human. PubMed:26176734[IF=2.91] Zhong, Zhiwei, et al. "miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer." Journal of cancer research and clinical oncology 138.10 (2012): 1781-1788. WB ; Human. PubMed:22806311[IF=2.9] Zhang, Jianhai, et al. "Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice." Food and Chemical Toxicology (2016). WB ; Mouse. PubMed:27237588[IF=2.883] Cheng et al. Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation. (2015) Cell.Biosc. 5:5 WB ; Rat. PubMed:25973172[IF=2.86] Meng, Yingying, et al. "Lauric acid stimulates mammary gland development of pubertal mice through activation of GPR84 and PI3K/Akt signaling pathway." Journal of Agricultural and Food Chemistry (2016). WB ; Mouse. PubMed:27978622[IF=2.82] Gao, Ling, et al. "Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition." Drug Design, Development and Therapy 11 (2017): 1789. WB ; Human. PubMed:28670112[IF=2.81] Yan, Xiaoting, et al. "Decreased expression of the vitamin D receptor in women with recurrent pregnancy loss." Archives of Biochemistry and Biophysics (2016). WB ; PubMed:27477959[IF=2.81] Wang et al. Molecular characterisation, evolution and expression of hypoxia-inducible factor in Aurelia sp.1. (2014) PLoS.On. 9:e100057 WB ; Jellyfish. PubMed:24926666[IF=2.81] Hu et al. Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition. (2016) PLoS.On. 11:e0153409 WB ; Mouse. PubMed:27088510[IF=2.81] Gao et al. Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes. (2016) PLoS.On. 11:e0147480 WB ; Mouse. PubMed:26799325[IF=2.81] Wang et al. Molecular characterisation, evolution and expression of hypoxia-inducible factor in Aurelia sp.1. (2014) PLoS.On. 9:e100057 WB ; Jellyfish. PubMed:24926666[IF=2.81] Hu et al. Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition. (2016) PLoS.On. 11:e0153409 WB ; Mouse. PubMed:27088510[IF=2.808] Huang M et al. A novel TRAIL mutant-TRAIL-Mu3 enhances the antitumor effects by the increased affinity and the up-expression of DR5 in pancreatic cancer. (2018).Cancer Chemotherapy and Pharmacology. Nov;82(5):829-838. WB ; Human. PubMed:30167846[IF=2.784] Ke M et al. Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/Akt-dependent Tbx-3 activation pathway. Int. J. Mol. Med. 2018 Jul;42(1):130-141. WB ; Marmoset . PubMed:29620145[IF=2.78] Ke et al. Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/‌Akt‑dependent Tbx‑3 activation pathway. (2018) Int.J.Mol.Med. WB ; Human. PubMed:29620145[IF=2.772] Lai, F. et al. Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson’s Disease.(2018). Neurochemical Research.Oct;43(10):1986-1999. WB ; PubMed:30171422[IF=2.766] Li et al. gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. (2014) PLoS.One. 9:e90878 WB ; Chicken. PubMed:24694742[IF=2.766] Zhou et al. Effect of bile pigments on the compromised gut barrier function in a rat model of bile duct ligation. (2014) PLoS.One. 9:e98905 WB ; Human. PubMed:24892651[IF=2.766] Yan et al. Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB Pathway. (2016) PLoS.One. 11:e0148536 WB ; Rat. PubMed:26918963[IF=2.759] Tong,et al.The protective effect of shikonin on renal tubular epithelial cell injury induced by high glucose.(2018) Biomedicine & Pharmacotherapy. 98:701-708. WB ; Rat. PubMed:29304496[IF=2.749] Han LQ et al. Overexpression of SREBF chaperone (SCAP) enhances nuclear SREBP1 translocation to upregulate fatty acid synthase (FASN) gene expression in bovine mammary epithelial cells.J Dairy Sci. 2018 Jul;101(7):6523-6531. WB ; Bovine. PubMed:29680640[IF=2.72] Wan, Dan, et al. "Resveratrol Provides Neuroprotection by Inhibiting Phosphodiesterases and Regulating the cAMP/AMPK/SIRT1 Pathway after Stroke in Rats." Brain Research Bulletin (2016). WB ; Rat. PubMed:26876758[IF=2.705] Xue Y et al. Methamphetamine reduces expressions of tight junction proteins, rearranges F-actincytoskeleton and increases the blood brain barrier permeability via the RhoA/ROCK-dependent pathway. Biochem Biophys Res Commun. 2019 Feb 5;509(2):395-401. WB ; Rat. PubMed:30594393[IF=2.705] Zhou S et al. Helicobacter pylori infection promotes epithelial-to-mesenchymal transition of gastric cells by upregulating LAPTM4B. Biochem Biophys Res Commun. 2019 Jun 30;514(3):893-900. IHC-P,ICF&WB ; Human. PubMed:31084933[IF=2.705] Zhou S et al. Helicobacter pylori infection promotes epithelial-to-mesenchymal transition of gastric cells by upregulating LAPTM4B. Biochem Biophys Res Commun. 2019 Jun 30;514(3):893-900. IHC-P,ICF&WB ; Human. PubMed:31084933[IF=2.705] Zhao Y et al. EZH2 regulates PD-L1 expression via HIF-1α in non-small cell lung cancer cells. Biochem Biophys Res Commun. 2019 Jul 19. pii: S0006-291X(19)31383-X. WB ; Mouse. PubMed:31331645[IF=2.7] Abdelzaher, Lobna A., et al. "Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations." Life Sciences (2016). WB ; Human. PubMed:26924495[IF=2.7] Kou, Shuming, et al. "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." Life Sciences (2016). WB ; Human. PubMed:26876917[IF=2.69] Lin, Caiyu, et al. "Lithocarpus Polystachyus Rehd Leaf Aqueous Extract Inhibits Human Breast Cancer Growth In Vitro and In Vivo." Nutrition and Cancer (2014). WB ; Human. PubMed:24660968[IF=2.688] Wang,et al.FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation.(2018) Experimental Biology and Medicine. 243:327-333. IHC-P ; Rat. PubMed:29307282[IF=2.688] Wang,et al.FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation.(2018) Experimental Biology and Medicine. 243:327-333. WB ; Rat. PubMed:29307282[IF=2.66] Li et al. Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway. (2016) Oncol.Rep. 36:936-44 WB ; Rat. PubMed:27277008[IF=2.66] Ye, Ruidong, et al. "Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats." Neurochemistry international 58.3 (2011): 391-398. WB ; Rat. PubMed:21185898[IF=2.66] Han, Xiaohua, et al. "Antioxidant action of 7, 8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity." Neurochemistry International (2013). WB ; Rat. PubMed:24220540[IF=2.66] Feng, Ming, et al. "Ulinastatin Attenuates Experimental Autoimmune Encephalomyelitis by Enhancing Anti-inflammatory Responses." Neurochemistry international (2013). WB ; Mouse. PubMed:24274996[IF=2.66] Lin, Qin-Qin, et al. "SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway." Cytokine 60.2 (2012): 447-455. WB ; PubMed:22717288[IF=2.66] Zhou, Gan, et al. "Diversity effect of capsaicin on different types of skeletal muscle." Molecular and Cellular Biochemistry(2017): 1-13. WB ; Rat. PubMed:29159769[IF=2.634] Zhou T et al. Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells.(2018) DNA Cell Biol. Oct 30. WB ; Human. PubMed:30376373[IF=2.62] Li, Zhifu, et al. "Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways." Inflammation 38.4 (2015): 1563-1572. WB ; Rat. PubMed:25687638[IF=2.61] Li, Yuan-bo, et al. "Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression." Molecular and Cellular Biochemistry: 1-10. Human. PubMed:27522665[IF=2.61] Yang, Yang, et al. "The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells." Leukemia Research 55 (2017): 91-96. WB ; Human. PubMed:28157629[IF=2.589] Xiao L et al. Profile of melatonin and its receptors and synthesizing enzymes in cumulus-oocyte complexes of the developing sheep antral follicle-a potential estradiol-mediated mechanism. Reprod Biol Endocrinol. 2019 Jan 3;17(1):1. WB ; Sheep. PubMed:30606208[IF=2.584] Gao et al. Carbon dots: a safe nanoscale substance for the immunologic system of mice. (2013) Nanoscale.Res.Let. 8:276 WB ; Mouse. PubMed:23758938[IF=2.583] Pang et al. The Role of IL-6RA in UHMWPE Promotes Proliferation in Fibro-Like Synovial Cells. (2018) Biomed.Res.Int. 2018:3928915 WB ; Human. PubMed:30426007[IF=2.58] Huang, Xu, et al. "ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells." Nanoscale Research Letters 12.1 (2017): 322. WB ; Mouse. PubMed:28472871[IF=2.58] Song, Liang-Li, et al. "Expression Characteristics of BMP2, BMPR-IA and Noggin in Different Stages of Hair Follicle in Yak Skin." General and Comparative Endocrinology (2017). WB ; Other Species. PubMed:29174869[IF=2.575] Tan LL et al. Inhibition of microRNA-17-5p reduces the inflammation and lipid accumulation, and up-regulates ATP-binding cassette transporterA1 in atherosclerosis. Journal of Pharmacological Sciences.2018. WB ; Mouse. PubMed:10.1016/j.jphs.2018.11.012[IF=2.566] Yang Z et al. Tenascin-C is involved in promotion of cancer stemness via the Akt/HIF1ɑ axis in esophageal squamous cell carcinoma.Exp Mol Pathol. 2019 Mar 20. WB ; Human. PubMed:30904401[IF=2.56] Wang, P. et al. "Attenuation of cytokine production of interleukine -2 and perforin in Two-way mixed lymphocyte reaction by highly efficient transduction of the recombinant adenovirus expressing ICP47 gene." Life Sci J 2013;10(3):963-969 WB ; PubMed:ISSN:1097-8135[IF=2.559] Jia C et al. Enhanced antitumor effect of combination of annexin A1 knockdown and bortezomib treatment in multiple myeloma in vitro and in vivo(2018) Biochem Biophys Res Commun.505(3):720-725 WB ; Mouse. PubMed:30292410[IF=2.55] Gao, Xinran, et al. "LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis." International Immunopharmacology 40 (2016): 392-399. WB ; Mouse. PubMed:27694040[IF=2.55] Wu, Xiaojuan, et al. "Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway." International Immunopharmacology 43 (2017): 164-171. WB ; Rat. PubMed:28061416[IF=2.55] Dinesh, Palani, and MahaboobKhan Rasool. "Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats." International Immunopharmacology 44 (2017): 26-37. WB ; Mouse. PubMed:28068647[IF=2.535] Song X et al. Anti-aging effects exerted by Tetramethylpyrazine enhances self-renewal and neuronal differentiation of rat bMSCs by suppressing NF-kB signaling. Biosci Rep. 2019 Jun 25;39(6). pii: BSR20190761. WB&ICC ; Rat. PubMed:31171713[IF=2.53] Yang, Zhang, et al. "Protective effects of mangiferin on cerebral ischemia–reperfusion injury and its mechanisms." European Journal of Pharmacology (2016). WB ; Rat. PubMed:26656757[IF=2.53] Yoshinaga, Ayana, et al. "NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation." European Journal of Pharmacology (2016). WB ; Human. PubMed:27105818[IF=2.53] Li Y et al. Ecdysterone Accelerates Healing of Radiation-Induced Oral Mucositis in Rats by Increasing Matrix Cell Proliferation. Radiat Res. 2019 Mar;191(3):237-244. WB ; Rat. PubMed:30694732[IF=2.52] Zhong, Zhiwei, et al. "MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells." Tumor Biology (2013): 1-7. WB ; Human. PubMed:23539435[IF=2.515] Sun W et al. Ageratina adenophora causes spleen toxicity by inducing oxidative stress and pyroptosis in mice. Royal Society Open Science.2019 Jul 26.6(7):190127. WB ; Mouse. PubMed:doi:10.1098/rsos.190127[IF=2.51] Ji-wei, Hu, et al. "Effects of Mfn2 Gene Overexpression on EGFR Expression and Angiogenesis of a Heterologous Graft Model for Human Breast Infiltrating Duct Carcinoma in Nude Mice." American Journal of Cancer Prevention 3.6 (2015): 117-121. WB ; Mouse. PubMed:12212066[IF=2.5] Ji, Xi-wei, et al. "Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208." Acta Pharmacologica Sinica (2015). WB ; Human. PubMed:25937633[IF=2.47] Meng, Yingying, et al. "Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice." Biochemical and Biophysical Research Communications (2017). WB ; Mouse. PubMed:28712865[IF=2.47] Xu, Dan-dan, et al. "TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells." Biochemical and biophysical research communications (2017). WB ; Rat. PubMed:29196266[IF=2.445] Song L et al. DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages. Gen Comp Endocrinol. 2019 Aug 12:113245. WB ; Yak. PubMed:31415730[IF=2.44] Zhang et al. Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. (2013) Reprod.Sc. 20:981-9 WB ; Human. PubMed:23322712[IF=2.43] Li, Ping, et al. "CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan." World Journal of Gastroenterology: WJG 21.5 (2015): 1518. WB ; Rat. PubMed:25663771[IF=2.42] Li, Taotao, et al. "Expression and cellular localization of double sex and mab-3 related transcription factor 1 in testes of postnatal Small-Tail Han sheep at different developmental stages." Gene (2017). WB ; Sheep. PubMed:29174386[IF=2.41] He, Siyi, et al. "miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway." Biochemical and biophysical research communications (2013). WB ; PubMed:24211202[IF=2.4] Sun, Yaojun, Bingyi Sun, and Rongli He. "Effect of the changes of NMDA receptor in hypothalamic paraventricular nucleus on cardiac function and sympathetic nervous activity in rats with heart failure." Biochemical and Biophysical Research Communications (2017). WB ; PubMed:28958939[IF=2.4] Liu, Minna, et al. "Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis." Biochemical and Biophysical Research Communications (2017). WB ; Human. PubMed:29277613[IF=2.38] Li, Gang, et al. "Ectopic WWOX Expression Inhibits Growth of 5637 Bladder Cancer Cell In Vitro and In Vivo." Cell Biochemistry and Biophysics: 1-9. WB ; Mouse. PubMed:27352332[IF=2.37] Huang, Huibin, et al. "Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen."International Journal of Endocrinology 2016 (2016). WB ; Human. PubMed:27525008[IF=2.37] Wang, Mengyuan, et al. "miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma." Biochemical and Biophysical Research Communications (2017). WB ; Human. PubMed:28595907[IF=2.35] Mao, Nan, et al. "Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitro." Acta Pharmacologica Sinica (2014). WB ; Mouse. PubMed:24632846[IF=2.35] Xu, Jiao-jiao, et al. "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." Acta Pharmacologica Sinica (2014). WB ; Human. PubMed:24909515[IF=2.341] Li,et al.Arcuate nucleus neurons are not essential for the preprandial peak in plasma ghrelin after neonatal monosodium glutamate treatment.(2018) International Journal of Molecular Medicine. 41:1635-1642. WB ; PubMed:29328403[IF=2.34] Liu et al. MicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2. (2017) Int.J.Mol.Med. 40:1851-1859 WB ; Rat. PubMed:29039453[IF=2.34] Zhang, Huagang, et al. "AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia." International Journal of Molecular Medicine. WB ; Rat. PubMed:29115402[IF=2.332] Zhao X et al. Total flavones of fermentation broth by co-culture of Coprinus comatus and Morchella esculenta induces an anti-inflammatory effect on LPS-stimulated RAW264.7 macrophages cells via the MAPK signaling pathway.(2018) Microb Pathog.125:431-437. WB ; Mouse. PubMed:30316005[IF=2.33] Pan, Lin, et al. "Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells." Molecular and cellular biochemistry 355.1-2 (2011): 257-263. WB ; Human. PubMed:21553022[IF=2.33] Tao, Hong, et al. "Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells." Molecular and Cellular Biochemistry (2014): 1-8. WB ; Human. PubMed:24833465[IF=2.33] Ma, Zhihong, et al. "Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells." Biomedicine & Pharmacotherapy 90 (2017): 361-367. WB ; Human. PubMed:28380411[IF=2.3] Mo, Xian-Gang, et al. "Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity." Microvascular research 81.2 (2011): 160-168. All. PubMed:21185840[IF=2.299] Gao XX et al. Effects of l-arginine on endometrial estrogen receptor α/β and progesterone receptor expression in nutrient-restricted sheep. Theriogenology. 2019 Jul 25;138:137-144. WB ; ewe. PubMed:31352175[IF=2.253] Wang Y et al. Seasonal expressions of COX-1, COX-2 and EP4 in the uteri of the wild Daurian ground squirrels (Spermophilus dauricus). Prostaglandins Other Lipid Mediat. 2019 Aug;143:106343. WB ; squirrel. PubMed:31195125[IF=2.25] Xiong, Zhang, et al. "Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease." Pharmacological Reports 63.5 (2011): 1101-1108. WB ; Human. PubMed:22180352[IF=2.25] Yang X et al.Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration and invasion, and promotes apoptosis in pancreatic cancer cells. (2018)Biochem. Cell Biol. WB ; Human. PubMed:30359541[IF=2.25] Ginsenoside metabolite compound K induces apoptosis and autophagy in non-small cell lung cancer cells via AMPK/mTOR and JNK pathways. C Li WB ; Human. PubMed:30475650[IF=2.238] Qiao Z et al. Casticin inhibits esophageal cancer cell proliferation and promotes apoptosis by regulating mitochondrial apoptotic and JNK signaling pathways.(2018)Naunyn Schmiedebergs Arch Pharmacol.Nov 17 WB ; Human. PubMed:30448926[IF=2.234] Qiao HH et al.Implications of alpha-synuclein nitration at tyrosine 39 in methamphetamine-induced neurotoxicity in vitro and in vivo. (2018) Neural Regen Res.14(2):319-327. WB ; Mouse&Human. PubMed:30531016[IF=2.21] Deng, Xiao Li, et al. "Comparative study on circulating endothelial progenitor cells in systemic lupus erythematosus patients at active stage." Rheumatology international 30.11 (2010): 1429-1436. WB ; Human. PubMed:19847436[IF=2.19] Zhang, Jin-ming, et al. "Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells." Environmental Toxicology and Pharmacology (2017). WB ; Human. PubMed:28364638[IF=2.17] Xiong, Xiaoqin, et al. "Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae." Zebrafish (2016). WB ; Others. PubMed:27509300[IF=2.16] Wang, Yi Ya, et al. "Epigenetic control of cyp19a1a expression is critical for high temperature induced Nile tilapia masculinization." Journal of Thermal Biology (2017). WB ; Other Species. PubMed:29037408[IF=2.15] Gao, Wei, et al. "Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma." Medical Oncology 30.2 (2013): 1-8. WB ; Human. PubMed:23536000[IF=2.15] Xu, Xilin, et al. "Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro." Biochemistry and Cell Biology (2017). WB ; Rabbit. PubMed:28662337[IF=2.14] Zhang, Zhan, et al. "Differential expression of beta-catenin and dickkopf-1 in the third trimester placentas from normal and preeclamptic pregnancies: a comparative study." Reproductive Biology and Endocrinology 11.1 (2013): 17. WB ; Human. PubMed:23452984[IF=2.136] Yao X et al. In vitro influence of selenium on the proliferation of and steroidogenesis in goat luteinized granulosa cells. Theriogenology. 2018 Jul 1;114:70-80. WB ; Goat. PubMed:29602134[IF=2.136] Shi L et al. Effects of maternal dietary selenium (Se-enriched yeast) on testis development, testosterone level and testicular steroidogenesis-related gene expression of their male kids in Taihang Black Goats. Theriogenology. 2018 Jul 1;114:95-102. WB ; Taihang Black Goat doe. PubMed:29605576[IF=2.13] Zhang, Xiangying, Shuping Song, and Huixin Luo. "Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway." Medicine 95.44 (2016): e5050. WB ; Mouse. PubMed:27858840[IF=2.12] Ruan Lin, et al. "Tetrandrine Attenuated Cerebral Ischemia/Reperfusion Injury and Induced Differential Proteomic Changes in a MCAO Mice Model Using 2-D DIGE." Neurochemical Research (2013). 1-9. WB ; Rat. PubMed:23780673[IF=2.1] Han et al. Apolipoprotein CIII regulates lipoprotein-associated phospholipase A2 expression via the MAPK and NFκB pathways. (2015) Biol.Open. 4:661-5 WB ; Porcine. PubMed:25836672[IF=2.09] Tao, Liu, et al. "In vitro study on human cytomegalovirus affecting early pregnancy villous EVT??s invasion function."Virology Journal 8.1 (2011): 1-8.D WB ; Human. PubMed:21392403[IF=2.072] Wang J et al. Oral supplementation with ginseng polysaccharide promotes food intake in mice. Brain Behav. 2019 Aug 8:e01340. WB ; Mouse. PubMed:31392839[IF=2.064] Yao Q et al.Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats.(2018)Evid Based Complement Alternat Med.Nov 15;2018:7943212. WB ; Rat. PubMed:30581486[IF=2.05] Nie, Lihong, et al. "The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure." Respiratory physiology & neurobiology (2013). WB ; Rat. PubMed:23665052[IF=2.05] He, Siyi, et al. "Protective role of downregulated MLK3 in myocardial adaptation to chronic hypoxia." Journal of Physiology and Biochemistry (2017): 1-10. WB ; Human. PubMed:28555332[IF=1.99] Yao, Xiaolei, et al. "Vitamin D receptor expression and potential role of vitamin D on cell proliferation and steroidogenesis in goat ovarian granulosa cells." Theriogenology (2017). WB ; Goat. PubMed:28797922[IF=1.953] Liu et al. Therapeutic effects of suppressors of cytokine signaling in diabetic nephropathy. (2014) J.Histochem.Cytoche. 62:119-28 WB ; Mouse. PubMed:24217922[IF=1.93] Xiong, Zhang, et al. "Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s Disease." Pharmacological Reports 63.5 (2011): 1101-1108. WB ; Human. PubMed:22180352[IF=1.922] Bai et al. miR‑29a‑3p represses proliferation and metastasis of gastric cancer cells via attenuating HAS3 levels. (2018) Mol.Med.Rep. 17:8145-8152 WB ; human. PubMed:29693123[IF=1.922] Li W et al. Vitamin K2 stimulates Mc3T3‑E1 osteoblast differentiation and mineralization through autophagy induction.Mol Med Rep. 2019 May;19(5):3676-3684. WB ; Mouse. PubMed:30896842[IF=1.922] Zhu Y et al. MicroRNA‑34a mediates atrial fibrillation through regulation of Ankyrin‑B expression.Mol Med Rep. 2018 Jun;17(6):8457-8465. WB ; Human. PubMed:29658562[IF=1.922] Liu Z et al. N-terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α alleviates phenylephrine‑induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes. Mol Med Rep. 2018 Aug;18(2):2142-2152. WB ; Rat. PubMed:29901150[IF=1.92] Yu et al. Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells. (2018) Mol.Med.Rep. 18:2124-2132 WB ; Rat. PubMed:29956802[IF=1.92] Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192. WB ; Dog. PubMed:27724864[IF=1.894] Zhang T et al. Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis. Med Sci Monit. 2019 Feb 15;25:1220-1231. WB ; Mouse. PubMed:30765684[IF=1.892] Li CL et al. Preparation and In Vivo Expression of CS-PEI/pCGRP Complex for Promoting Fracture Healing. International Journal of Polymer Science.2019 9432194. WB ; Rat. PubMed:doi:10.1155/2019/9432194[IF=1.89] Zong, Shaohui, et al. "Effects of Polygonatum sibiricum polysaccharide on the osteogenic differentiation of bone mesenchymal stem cells in mice." International Journal of Clinical and Experimental Pathology8.6 (2015): 6169-6180. WB ; Mouse. PubMed:26261494[IF=1.871] Huang XW et al. Scutellarein suppresses Aβ‑induced memory impairment via inhibition of the NF‑κB pathway in vivo and in vitro. Oncol Lett. 2019 Jun;17(6):5581-5589. WB ; Rat. PubMed:31186780[IF=1.871] Meng H et al. NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT. ONCOLOGY LETTERS.2019 18: 4022-4029. WB ; Human. PubMed:DOI: 10.3892/ol.2019.10756[IF=1.87] Xin, Ruijuan, et al. "MicroRNA-214 promotes peritoneal metastasis through regulating PTEN negatively in gastric cancer." Clinics and Research in Hepatology and Gastroenterology (2016). WB ; Human. PubMed:27339596[IF=1.84] Zhao, Yong, et al. "Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production." Theriogenology (2016). WB ; Sheep. PubMed:28043364[IF=1.84] Shi, Lei, et al. "Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro." Theriogenology (2017). WB ; Sheep. PubMed:28257863[IF=1.84] Yao, Xiaolei, et al. "Characterization of GALNTL5 gene sequence and expression in ovine testes and sperm." Theriogenology (2017). WB ; Sheep. PubMed:28460680[IF=1.83] Li, Gongchu, et al. "Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells." Glycoconjugate Journal (2017): 1-10. WB ; Human. PubMed:28349379[IF=1.8] Zhao, Yangfei, et al. "Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride."Biological Trace Element Research (2016): 1-7. WB ; Mouse. PubMed:27368532[IF=1.77] Chen, Cui-Ying, et al. "Characterization of cytotoxicity-related gene expression in response to virulent Marek??s disease virus infection in the bursa of Fabricius."Research in veterinary science (2012).q WB ; Chicken. PubMed:23164636[IF=1.75] Vinothkumar, G., et al. "Abnormal Amyloid β 42 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: A small scale case control study comparison with Alzheimer's disease." BBA Clinical (2017). WB ; Human. PubMed:28702365[IF=1.747] Zeng B et al. The beneficial effects of Moringa oleifera leaf on reproductive performance in mice. Food Sci Nutr. 2019 Jan 22;7(2):738-746. WB ; Mouse. PubMed:30847152[IF=1.747] Chen XP et al. Lower methionine/cystine ratio in low‐protein diet improves animal reproductive performance by modulating methionine cycle. Food Sci Nutr. 2019;00:1–9. WB ; Mouse. PubMed:doi:10.1002/fsn3.1128[IF=1.74] Wang, Peng, et al. "Recombinant adenovirus expressing ICP47 gene suppresses the ability of dendritic cells by restricting specific T cell responses." Cellular Immunology (2013). WB ; Human. PubMed:23774531[IF=1.74] Li, Hui, et al. "The Role of ΔFosB on the Pro-survival Effect of PTHrP in Goat Mammary Epithelial Cells." Applied Biochemistry and Biotechnology(2016): 1-10. WB ; Goat. PubMed:27193254[IF=1.73] Zeng, Q. J., et al. "Decorin-induced proliferation of avian myoblasts involves the myostatin/Smad signaling pathway." Poultry Science 93.1 (2014): 138-146. WB ; PubMed:24570433[IF=1.72] Liang, Guojuan, et al. "The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats." Behavioral and Brain Functions 11.1 (2015): 1. WB ; Rat. PubMed:25907417[IF=1.7] Yan, An, et al. "Pro-survival effect of Dock180 overexpression on rat-derived H9C2 cardiomyocytes." Medical science monitor basic research 19 (2013): 12-19. WB ; Rat. PubMed:23314417[IF=1.692] Tong,et al.Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway.(2018) Molecular Medicine Reports. 17:5320-5327. IHC-P ; Mouse. PubMed:29393404[IF=1.69] Li et al. Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation. (2017) Mol.Med.Rep. 16:4455-4462 WB ; Human, Rat. PubMed:28791384[IF=1.69] GAO, DAN, et al. "Effect of peritoneal dialysis on expression of vascular endothelial growth factor, basic fibroblast growth factor and endostatin of the peritoneum in peritoneal dialysis patients." Nephrology 16.8 (2011): 736-742. WB ; Human. PubMed:21771176[IF=1.69] Xin, Ji‑Le, et al. "Protective effects of Cervus nippon Temminck velvet antler polypeptides against MPP+‑induced cytotoxicity in SH‑SY5Y neuroblastoma cells." Molecular Medicine Reports 16.4 (2017): 5143-5150. WB ; Human. PubMed:28849030[IF=1.69] Liang et al. Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells. (2015) Mol.Med.Re. 12:2577-83 WB ; Human. PubMed:25936769[IF=1.66] Hu et al. Upregulation of the MCL-1S protein variant following dihydroartemisinin treatment induces apoptosis in cholangiocarcinoma cells. (2015) Oncol.Lett. 10:3545-3550 WB ; Human. PubMed:26788167[IF=1.66] Xu, Dan-dan, et al. "17β-Estradiol and progesterone decrease MDP induced NOD2 expression in bovine mammary epithelial cells." Veterinary Immunology and Immunopathology (2017). WB ; Bovine. PubMed:28615128[IF=1.654] Li T et al. Histomorphological Comparisons and Expression Patterns of BOLL Gene in Sheep Testes at Different Development Stages.Animals (Basel). 2019 Mar 21;9(3). WB ; Sheep. PubMed:30901845[IF=1.654] Yao C et al. Data Mining and Validation of AMPK Pathway as a Novel Candidate Role Affecting Intramuscular Fat Content in Pigs. Animals (Basel). 2019 Apr 1;9(4). pii: E137. WB ; Pig. PubMed:30939765[IF=1.652] Wang F et al. Gypenosides attenuate lipopolysaccharide-induced optic neuritis in rats. Acta Histochem. 2018 May;120(4):340-346. WB ; Rat. PubMed:29559175[IF=1.64] Fan, Wen-Jie, et al. "NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows." Biotechnology Letters: 1-11. WB ; Bovine. PubMed:27447467[IF=1.638] Duan H et al. Expression of estrogen receptor, androgen receptor, and progesterone nuclear receptor in sheep uterus during the estrous cycle. Reprod Domest Anim. 2019 Jun 12. WB ; Sheep. PubMed:31188500[IF=1.61] Jiang, Yun-Yun, et al. "Characterization and Expression of Chicken Selenoprotein U." Biological Trace Element Research (2015): 1-9. WB ; PubMed:25876085[IF=1.607] Zhao B et al. N‐Acetyl‐d‐galactosamine prevents soya bean agglutinin‐induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Apr 1. WB ; Porcine. PubMed:30934149[IF=1.58] Zhang et al. Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal microcirculation. (2015) J.Geriatr.Cardiol. 12:353-65 WB ; Rat. PubMed:26346675[IF=1.58] Lu, Wei, et al. "MicroRNA-421 enhances cell migration and invasion by down-regulating TIMP-2 in glioblastoma." Int J Clin Exp Med 9.8 (2016): 15876-15883. WB ; Human. PubMed:0[IF=1.56] Xiang, Yan, et al. "Effect of Yi Guan Jian decoction on differentiation of bone marrow mesenchymalstem cells into hepatocyte-like cells in dimethylnitrosamine-induced liver cirrhosis in mice." Molecular Medicine Reports. WB ; Mouse. PubMed:28035356[IF=1.56] Du, Jinghua, et al. "TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice." Molecular medicine reports 13.3 (2016): 2159-2166. WB ; Mouse. PubMed:26781175[IF=1.559] Li et al. Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway. (2015) Mol.Med.Re. 11:4454-62 WB ; Mouse. PubMed:25625500[IF=1.55] Chang, Liang, et al. "Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and-9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma." Molecular Medicine Reports. (2015). WB ; PubMed:26299938[IF=1.55] Hou, Yan, et al. "miR‑215 functions as a tumor suppressor and directly targets ZEB2 in human non‑small cell lung cancer." Oncology Letters. WB ; Human. PubMed:26622784[IF=1.55] Qi, Zhonghua, et al. "Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model." Molecular Medicine Reports. WB ; PubMed:26300349[IF=1.55] Chang, Liang, et al. "Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and-9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma. Corrigendum in/mmr/12/5/7815." Molecular medicine reports 12.5 (2015): 6702-6710. WB ; Human. PubMed:26299938[IF=1.55] Cheng, Yunpeng, et al. "Effect of oxidized low-density lipoprotein on the expression of the prorenin receptor in human aortic smooth muscle cells."Molecular medicine reports 11.6 (2015): 4341-4344. WB ; Human. PubMed:25626130[IF=1.55] Zhang, Zhongti, et al. "Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck." Oncology Letters 13.5 (2017): 3191-3197. WB ; Human. PubMed:28521425[IF=1.55] Lv, Liang, et al. "Invasive Pituitary Adenoma-Derived Tumor-Associated Fibroblasts Promote Tumor Progression both In Vitro and In Vivo." Experimental and Clinical Endocrinology & Diabetes (2017). WB ; Rat. PubMed:29117616[IF=1.52] Zhu et al. Expression of serotonin receptors in the colonic tissue of chronic diarrhea rats. (2016) Saudi.J.Gastroentero. 22:234-9 WB ; Rat. PubMed:27184643[IF=1.52] Liang Q et al. Evaluation of a modified rat model for functional dyspepsia.Saudi J Gastroenterol. 2018 Jul-Aug;24(4):228-235. WB ; Rat. PubMed:29652029[IF=1.496] Guo et al. Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression. (2017) Dev.Growth.Differ. 59:94-103 WB ; Mouse. PubMed:28211947[IF=1.482] Ji and Jiang Effect of shRNA-mediated inhibition of Nanog gene expression on the behavior of human gastric cancer cells. (2013) Oncol.Let. 6:367-374 WB ; Human. PubMed:24137331[IF=1.48] Yan, Weihong, et al. "The effect of miR-146a on STAT1 expression and apoptosis in acute lymphoblastic leukemia Jurkat cells." Oncology Letters. WB ; Human. PubMed:28123535[IF=1.466] Li G et al. Effect of lncRNA ANRIL knockdown on proliferation and cisplatin chemoresistance of osteosarcoma cells in vitro. Pathol Res Pract. 2019 Jan 30. pii: S0344-0338(18)31655-8. WB ; Human. PubMed:30777616[IF=1.44] Zhou F et al.Salidroside protected against MPP+‐induced Parkinson's disease in PC12 cells by inhibiting inflammation, oxidative stress and cell apoptosis.(2018) Biotechnol Appl Biochem. WB ; Rat . PubMed:30548933[IF=1.438] Jiang JY et al. Effects of estradiol and progesterone on secretion of epidermal growth factor and insulin-like growth factor-1 in cultured yak endometrial epithelial cells. Tissue Cell. 2018 Jun;52:28-34. WB ; Yak. PubMed:29857825[IF=1.422] Ran M et al. miR-26a suppresses autophagy in swine Sertoli cells by targeting ULK2.Reprod Domest Anim. 2018 Aug;53(4):864-871. WB ; Shaziling boar. PubMed:29761550[IF=1.42] Karaboga, İhsan, Selim Demirtas, and Turan Karaca. "Investigation of the relationship between the Th17/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats." Iranian Journal of Basic Medical Sciences 20.8 (2017): 870-879. WB ; Rat. PubMed:29085578[IF=1.41] Wu and Huang Synergistic enhancement of matrix metalloproteinase-9 expression and pro-inflammatory cytokines by influenza virus infection and oxidized-LDL treatment in human endothelial cells. (2017) Exp.Ther.Med. 14:4579-4585 WB ; human. PubMed:29104665[IF=1.41] Song et al. Effects of HSYA on the proliferation and apoptosis of MSCs exposed to hypoxic and serum deprivation conditions. (2018) Exp.Ther.Med. 15:5251-5260 WB ; Rat. PubMed:29904409[IF=1.396] Su N et al. Wnt/β-catenin deficiency inhibits multiple myeloma cell growth via AMPK/mTOR signaling. Int J Clin Exp Med. 2018;11(6):5657-5665. WB ; Human. PubMed:ISSN:1940-5901/IJCEM0064342.[IF=1.39] Chen et al. Wnt4 overexpression promotes thymoma development through a JNK-mediated planar cell polarity-like pathway. (2018) Oncol.Lett. 15:83-90 WB ; Human. PubMed:29387212[IF=1.39] Cao et al. MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7. (2018) Oncol.Lett. 15:453-458 WB ; Human. PubMed:29422961[IF=1.39] Chen, Yuan, et al. "Wnt4 overexpression promotes thymoma development through a JNK‑mediated planar cell polarity‑like pathway." Oncology Letters. WB ; Human. PubMed:29387212[IF=1.39] Chang et al. MicroRNA-133b inhibits cell migration and invasion by targeting matrix metalloproteinase 14 in glioblastoma. (2015) Oncol.Let. 10:2781-2786 WB ; Human. PubMed:26722242[IF=1.39] Chang et al. MicroRNA-133b inhibits cell migration and invasion by targeting matrix metalloproteinase 14 in glioblastoma. (2015) Oncol.Let. 10:2781-2786 WB ; Human. PubMed:26722242[IF=1.38] Huang, Chen, et al. "Expression, purification, and functional characterization of recombinant PTD-SARA." Acta biochimica et biophysica Sinica 43.2 (2011): 110-117. WB ; PubMed:21266541[IF=1.37] Zhu et al. Expression of serotonin receptors in the colonic tissue of chronic diarrhea rats. (2016) Saudi.J.Gastroentero. 22:234-9 WB ; Rat. PubMed:27184643[IF=1.344] Gu et al. Angiopoietin-1 and Angiopoietin-2 Expression Imbalance Influence in Early Period After Subarachnoid Hemorrhage. (2016) Int.Neurourol.. 20:288-295 WB ; Rat. PubMed:28043115[IF=1.311] Nie Y et al. KH-type splicing regulatory protein is regulated by nuclear factor-κB signaling to mediate innate immunity in Caco-2 cells infected by Salmonella enteritidis.Folia Microbiol (Praha). 2018 Nov;63(6):669-676. WB ; Human. PubMed:29728998[IF=1.31] Wang, Chunqiang, Wei Ma, and Yuhong Su. "NF-??B Pathway Contributes to Cadmium-Induced Apoptosis of Porcine Granulosa Cells."Biological trace element research (2013): 1-8.c WB ; Pig. PubMed:23575899[IF=1.28] Wu, Xue-Mei, et al. "Inhibition of connexin 36 decreases seizure activity in the Kainic acid-induced rat model of epilepsy." Int J Clin Exp Med 9.2 (2016): 2277-2284. WB ; Rat. PubMed:0[IF=1.28] Li, Yunlun, et al. "Mechanism of the protective effects of the combined treatment with rhynchophylla total alkaloids and sinapine thiocyanate against a prothrombotic state caused by vascular endothelial cell inflammatory damage." Experimental and Therapeutic Medicine. WB ; Mouse. PubMed:28587383[IF=1.28] Zhong et al. Inhibition of proliferation of human lung cancer cells by green tea catechins is mediated by upregulation of let-7. (2012) Exp.Ther.Me. 4:267-272 WB ; Human. PubMed:22970031[IF=1.28] Yang et al. Effect of saw palmetto extract on PI3K cell signaling transduction in human glioma. (2014) Exp.Ther.Me. 8:563-566 WB ; Human. PubMed:25009620[IF=1.25] Zhao, Yu, and Shijun Wang. "Neural Stem Cell Transplantation Inhibits Apoptosis through Activation of MAPK/ERK Signaling Pathway in Cerebral Ischemia/Reperfusion Rats." International Journal of Clinical and Experimental Neurology 1.1 (2013): 5-11. WB ; Rat. PubMed:0[IF=1.22] Ma, Lili, et al. "Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats." Iranian Journal of Basic Medical Sciences 20.6 (2017): 715-721. WB ; Rat. PubMed:0[IF=1.22] Ma et al. Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats. (2017) Iran.J.Basic.Med.Sc. 20:715-721 WB ; Rat. PubMed:28868127[IF=1.189] Cai YH et al. Riboflavin/ultraviolet A-induced collagen cross-linking in rabbit corneal scar. Int J Ophthalmol. 2019 Jan 18;12(1):46-50. WB ; Rabbit. PubMed:30662839[IF=1.189] Jiang JQ et al. Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis. Int J Ophthalmol. 2019 Jun 18;12(6):898-903. WB ; Mouse. PubMed:31236343[IF=1.166] Liu M et al. Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.Int J Ophthalmol. 2018 Apr 18;11(4):548-552. WB ; Mouse. PubMed:29675369[IF=1.14] Wang, J., et al. "Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway." Brazilian Journal of Medical and Biological Research (2014): 000-000. WB ; Mouse. PubMed:25517918[IF=1.1] Zhou, Jing, et al. "Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats."?Experimental & Clinical Cardiology?18.2 (2013): e95. WB ; Rat. PubMed:23940455[IF=1.09] Zhao, Zhilong, et al. "Expression of natriuretic peptide receptor-A in esophageal squamous cell carcinomas and the relationship with tumor invasion and migration." World Journal of Surgical Oncology 12.1 (2014): 154. WB ; Human. PubMed:24885858[IF=1.07] Liu, Cui-Zhen, et al. "HBSP attenuates lipopolysaccharide-induced inflammatory response in human renal proximal tubular epithelial cells by induction of Nrf2 via PI3K/Akt pathway." Int J Clin Exp Med 10.1 (2017): 587-597. WB ; Human. PubMed:0[IF=1] Yang, Huihai, et al. "Anticancer activity in vitro and biological safety evaluation in vivo of Sika deer antler protein." Journal of Food Biochemistry(2017). WB ; Other Species. PubMed:10.1111/jfbc.12421[IF=1] Gou, Xun, et al. "Effect of social interaction on learning and memory of morphine withdrawal mice." Int J Clin Exp Med10.10 (2017): 14477-14485. WB ; Mouse. PubMed:0[IF=.9] Zhang, Xiao-ling, et al. "Vascular endothelial growth factor up-regulates the expression of intracellular adhesion molecule-1 in retinal endothelial cells via reactive oxygen species, but not nitric oxide." Chinese Medical Journal (English Edition) 122.3 (2009): 338. WB ; Bovine. PubMed:19236815[IF=.9] Suzuki, Tomoyuki, et al. "Atrial natriuretic peptide induces peroxisome proliferator activated receptor γ during cardiac ischemia–reperfusion in swine heart." General Thoracic and Cardiovascular Surgery (2016): 1-11. WB ; Pig. PubMed:27510704[IF=.84] Liu, Xiao-Lan, et al. "Increased expression of Dock180 protein in the noninfarcted myocardium in rats." Journal of the Chinese Medical Association 76.3 (2013): 164-168. WB ; Rat. PubMed:23497970[IF=.78] Ma, X., et al. "Molecular cloning and expression vector construction of bovine TRIM28 Genet. Mol. Res. 15 (2)." Genet. Mol. Res 15: 2. WB ; Bovine. PubMed:27420979[IF=.73] Asada, Dai, Toshiyuki Itoi, and Kenji Hamaoka. "The tolerance to ischemia reperfusion injury in a congenital heart disease model." Pediatrics International (2016) WB ; Rat. PubMed:27097979[IF=.63] Mu, Yang, et al. "Up-regulation of phosphorylated ATM/ATR substrate/Akt expression by phenylephrine in peri-infarct myocardium in rats." Acta Cardiol Sin 27.3 (2011): 182-8. WB ; Rat. PubMed:0[IF=.6] Yin, Zhihong, et al. "Identification of differentially expressed Gnαs and Gnα11 in sheep (Ovis aries) skins associated with white and black coat colors." Acta histochemica (2016). WB ; Sheep. PubMed:26767972[IF=.57] Shi, Hua-Li, et al. "Effect of polygonimitin C on bone formation and resorption in human osteoblast-like MG63 cells." Tropical Journal of Pharmaceutical Research 16.7 (2017): 1595-1600. WB ; Human. PubMed:10.4314/tjpr.v16i7.18[IF=.437] Ma X et al. Expression and characterization of a lysine rich protein in cow milk. Indian J. Anim. Res.,2019 53(7):874-879. WB ; Human. PubMed:doi:10.18805/ijar. B-882[IF=.34] Wang, Gui-Jun, et al. "Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance." Experimental and Therapeutic Medicine. WB ; Human. PubMed:24396436[IF=.181] Zhao R et al. IE86 Inhibits the apoptosis and promotes the cell proliferation of glioma cells via the hnRNP A2/B1-mediated alternative splicing of Bcl-x. Int J Clin Exp Pathol 2019;12(7):2775-2785 WB ; Human. PubMed:ISSN:1936-2625/IJCEP0094447[IF=.181] Jiao M et al. Protective effect of hydrogen sulfide against neuronal apoptosis via inhibiting neuroinflammation in Parkinson rats. Int J Clin Exp Med 2019;12(5):4935-4941 WB ; Rat. PubMed:ISSN:1940-5901[IF=.13] Zhang, Z. J., et al. "Prospective experimental studies on the renal protective effect of ulinastatin after paraquat poisoning." World J Emerg Med 3.4 (2012): 299-304. WB ; Rat. PubMed:25215081[IF=0] Yin et al. Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin. (2014) Drug.Des.Devel.Ther. 8:1817-25 WB/FC ; Human. PubMed:25336924[IF=0] Li et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. (2015) J.Exp.Clin.Cancer.Res. 34:137 WB ; Human. PubMed:26538209[IF=0] Li et al. Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4(+)CD25(+) regulatory T cells. (2016) Neuropsychiatr.Dis.Treat. 12:883-96 WB ; Rat. PubMed:27143890[IF=0] Wang et al. Time-dependent effects of late-onset dietary intake of salidroside on lifespan and age-related biomarkers of the annual fish Nothobranchius guentheri. (2018) Oncotarget. 9:14882-14894 WB ; Fish. PubMed:29599913[IF=0] Sakaguchi et al. Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma. (2018) Oncotarget. 9:23003-23017 WB ; human. PubMed:29796168[IF=0] Zhu et al. Vγ9Vδ2 T cells inhibit immature dendritic cell transdifferentiation into osteoclasts through downregulation of RANK, c‑Fos and ATP6V0D2. (2018) Int.J.Mol.Med. 42:2071-2079 WB ; Human . PubMed:30066839[IF=0] Sondag, Gregory R. OSTEOACTIVIN AND CD44: A NOVEL INTERACTION REGULATING BONE CELL DIFFERENTIATION AND FUNCTION. Diss. Kent State University, 2015. WB ; Mouse. PubMed:000[IF=0] Xu, Jing, et al. "Construction of Conveniently Screening pLKO. 1-TRC Vector Tagged with TurboGFP." Applied Biochemistry and Biotechnology(2016): 1-11. WB ; Human. PubMed:27730520[IF=0] Li et al. Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells. (2016) Sci.Re. 6:30496 WB ; Human. PubMed:27460655[IF=0] Lai et al. PKCδ silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity. (2017) Biosci.Re. 37 WB ; Human. PubMed:29046367[IF=0] Zhang et al. Expression of Heat Shock Protein-27 (Hsp27) and P38MAPK in Esophageal Squamous Cell Carcinoma. (2017) Med.Sci.Moni. 23:5246-5253 WB ; Human. PubMed:29099815[IF=0] Liu et al. PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways. (2017) Oncotarget. 8:99901-99912 WB ; PubMed:29245948[IF=0] Luan et al. Long non-coding RNA MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p. (2017) Oncotarget. 8:76153-76164 WB ; PubMed:29100300[IF=0] Nie et al. The effect of depression on fracture healing and osteoblast differentiation in rats. (2018) Neuropsychiatr.Dis.Treat. 14:1705-1713 WB ; Rat. PubMed:29988656[IF=0] Han B et al. 8-Cetylcoptisine, a new coptisine derivative, induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest in human A549 cells.(2018)Chem Biol Interact.;299:27-36. WB ; Mouse. PubMed:30472432[IF=0] Kaushal P et al. Ameliorative role of antioxidant supplementation on sodium-arsenite induced adverse effects on the developing rat cerebellum. Journal of Ayurveda and Integrative Medicine.2019 WB ; Rat. PubMed:doi:10.1016/j.jaim.2018.02.138 [IF=0] Tang Y et al. Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1Deposition and Activating PKA in APP/PS1 Double Transgenic Mice. Neural Plast. 2019 May 15;2019:2823679. WB ; Rat. PubMed:31223308[IF=0] Zhang XD et al. MiR-26a promotes apoptosis of porcine granulosa cells by targeting the 3β-hydroxysteroid-Δ24-reductase gene. Asian-Australas J Anim Sci. 2019,July 1. WB ; Pig. PubMed:doi:10.5713/ajas.19.0173[IF=0] Wang T et al. Picroside II protects SH‐SY5Y cells from autophagy and apoptosis following oxygen glucose deprivation/reoxygen injury by inhibting JNK signal pathway. The Anatomical Record. 2019,July 11. WB ; Human. PubMed:doi:10.1002/ar.24214[IF=0] Li T et al. Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis. R. Soc. open sci. 2019,6: 181604. WB ; Sheep. PubMed:doi:10.1098/rsos.181604[IF=0] Liao XD et al. Effect of all-trans retinoic acid on casein and fatty acid synthesis in MAC-T cells. Asian-Australas J Anim Sci. 2019 Aug 23. WB ; bovine. PubMed:31480153[IF=0] Jin Y et al. TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells. International Journal of Biological Macromolecules. 2018. WB ; Human. PubMed:10.1016/j.ijbiomac.2018.11.269[IF=0] Wang M et al. Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor-β1-mediated Smad and mitogen-activated protein kinase signaling transductions in vivo and in vitro. Exp Ther Med. 2019 Jan;17(1):251-259. WB ; Mouse. PubMed:30651790[IF=4.255] Chen L et al. Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α. Atherosclerosis. 2019 Sep 11;290:19-30. WB ; Mouse&Human. PubMed:31557675[IF=3.414] Li ZH et al. You-Gui-Yin improved the reproductive dysfunction of male rats with chronic kidney disease via regulating the HIF1α-STAT5 pathway. J Ethnopharmacol. 2020 Jan 10;246:112240. WB ; Rat. PubMed:31526861[IF=3.244] Zhou L et al. JLX001 Ameliorates Ischemia/Reperfusion Injury by Reducing Neuronal Apoptosis Via Downregulating JNK Signaling Pathway. Neuroscience 418 (2019) 189–204. WB ; Rat. PubMed:doi:10.1016/j.neuroscience.2019.08.053[IF=2.302] Deng K et al. miR-27a is an important adipogenesis regulator associated with differential lipid accumulation between intramuscular and subcutaneous adipose tissues of sheep. Domestic Animal Endocrinology.2019Sep. WB ; Sheep. PubMed:doi:10.1016/j.domaniend.2019.106393[IF=2.302] Li Q et al. All-trans retinoic acid regulates sheep primary myoblasts proliferation and differentiation in vitro. Domestic Animal Endocrinology,2019 106394. WB ; Sheep. PubMed:doi:10.1016/j.domaniend.2019.106394[IF=2.299] Yang WR et al. Oxidative stress mediates heat-induced changes of tight junction proteins in porcine Sertoli cells via inhibiting CaMKKβ-AMPK pathway. Theriogenology. 2019 Sep 19;142:104-113. WB ; Piglet. PubMed:31586867[IF=1.376] Song MN et al. Effects of Actigen, a second-generation mannan rich fraction, in antibiotics_x0002_free diets on growth performance, intestinal barrier functions and inflammation in weaned piglets. Livestock Science 229 (2019) 4–12. WB ; Piglet. PubMed:doi:10.1016/j.livsci.2019.09.006[IF=1.26] Qian ZK et al. Alisma orientalis (Sam.) juzep polysaccharide-regulated glucose-lipid metabolism in experimental rats and cell model of diabetes mellitus with regulation of miR-126. Pharmacognosy Magazine,2019 15(65): 652-658. WB ; Human. PubMed:DOI: 10.4103/pm.pm_441_18[IF=0] Xu LR et al. Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments. ChemRxiv.2019Sep. WB ; Human. PubMed:doi:10.26434/chemrxiv.9755543.v1[IF=0] Xu YY et al. L-type Calcium Channels are Involved in Iron-induced Neurotoxicity in Primary Cultured Ventral Mesencephalon Neurons of Rats. Neurosci Bull. 2019 Sep 3. WB ; Rat. PubMed:31482520[IF=2.515] Li T et al. Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis.R Soc Open Sci. 2019 Jul 3;6(7):181604. WB ; Sheep. PubMed:31417691[IF=3.331] Wang X et al. Characterization of GLOD4 in Leydig Cells of Tibetan Sheep During Different Stages of Maturity.Genes (Basel). 2019 Oct 12;10(10). pii: E796. WB ; Sheep. PubMed:31614839产品类型内参抗体研究领域肿瘤细胞生物信号转导细胞骨架抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Mouse, Rat, Chicken, Dog, Rabbit, Sheep, Bee, Fish, Guinea Pig, Hamster, Cat, mt,op产品应用WB=1:5000-20000 ELISA=1:5000-20000 IHC-P=1:500-1000 Flow-Cyt=1μg/Test ICC=1:100 （石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.分子量42kDa细胞定位细胞浆性状Liquid浓度1mg/ml免疫原Synthetic MAP peptide derived from human beta-Actin:1-200/375 亚型IgG纯化方法affinity purified by Protein A储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍Loading ControlThis gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008].Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.Subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2.Subcellular Location:Cytoplasm. cytoskeleton.Tissue Specificity:Ubiquitously expressed in all eukaryotic cells.Post-translational modifications:ISGylated.Oxidation of Met-44 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.DISEASE:Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.Similarity:Belongs to the actin family.SWISS:P60709Gene ID:60Database links:Entrez Gene: 396526 ChickenEntrez Gene: 60 HumanEntrez Gene: 11461 MouseEntrez Gene: 100009272 RabbitEntrez Gene: 81822 RatOmim: 102630 HumanSwissProt: P60706 ChickenSwissProt: P60712 CowSwissProt: P60708 HorseSwissProt: P60709 HumanSwissProt: P60710 MouseSwissProt: P29751 RabbitSwissProt: P60711 RatSwissProt: P60713 SheepUnigene: 520640 HumanUnigene: 708120 HumanUnigene: 727576 HumanUnigene: 328431 MouseUnigene: 391967 MouseUnigene: 94978 RatImportant Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.内参抗体β-Actin是横纹肌肌纤维中的一种主要蛋白质成分，也是肌肉细丝及细胞骨架微丝的主要成分。具有收缩功能，分布广泛，具有高度保守性，在细胞中的表达相对稳定，因此常被用作校正系统的内参。β-Actin分子量为42 kDa，此抗体主要用于标记平滑肌及其来源的肿瘤。我公司开发的β-Actin抗体已被国内外广大科研工作者使用，被称谓：质量信得过产品.产品图片Sample:Lung (Mouse) Lysate at 40 ugUterus (Mouse) Lysate at 40 ugSmall intestine (Mouse) Lysate at 40 ugPrimary: Anti- beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:A549 Cell (Human) Lysate at 30 ugPrimary: Lane1: Anti-beta-Actin (bs-0061R) at 1/500 dilutionLane2: Anti-beta-Actin (bs-0061R) at 1/1000 dilutionLane3: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane4: Anti-beta-Actin (bs-0061R) at 1/4000 dilutionLane5: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane6: Anti-beta-Actin (bs-0061R) at 1/8000 dilutionLane7: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:A549 Cell (Human) Lysate at 30 ugPrimary: Lane1: Anti-beta-Actin (bs-0061R) at 1/500 dilutionLane2: Anti-beta-Actin (bs-0061R) at 1/1000 dilutionLane3: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane4: Anti-beta-Actin (bs-0061R) at 1/4000 dilutionLane5: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane6: Anti-beta-Actin (bs-0061R) at 1/8000 dilutionLane7: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:Lane1: 293T Cell Lysate at 25 ugLane2: A549 Cell Lysate at 25 ugLane3: A431 Cell Lysate at 25 ugPrimary: Anti- beta-Actin (bs-0061R) at 1/1000 and 1/5000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42kDObserved band size: 42 kDSample: Lung lysate at 30ug;Primary: Anti-beta-actin (bs-0061R) at 1:1000 dilutionSecondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1:3000 dilutionPredicted band size : 42kDObserved band size : 42kDSample:Lane 1: SH-SY5Y (Human) Lysate at 40 ugLane 2: SH-SY5Y (Human) Lysate at 40 ugLane 3: SH-SY5Y (Human) Lysate at 40 ugLane 4: SH-SY5Y (Human) Lysate at 40 ugPrimary:Lane 1: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane 2: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane 3: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionLane 4: Anti-beta-Actin (bs-0061R) at 1/20000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:Lane 1: Lymph node (Rat) Lysate at 40 ugLane 2: Lymph node (Rat) Lysate at 40 ugLane 3: Lymph node (Rat) Lysate at 40 ugLane 4: Lymph node (Rat) Lysate at 40 ugLane 5: Lymph node (Rat) Lysate at 40 ugPrimary:Lane 1: Anti-beta-Actin (bs-0061R) at 1/1000 dilutionLane 2: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane 3: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane 4: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionLane 5: Anti-beta-Actin (bs-0061R) at 1/20000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:Lane 1: Thymus (Mouse) Lysate at 40 ugLane 2: Thymus (Mouse) Lysate at 40 ugLane 3: Thymus (Mouse) Lysate at 40 ugLane 4: Thymus (Mouse) Lysate at 40 ugLane 5: Thymus (Mouse) Lysate at 40 ugPrimary:Lane 1: Anti-beta-Actin (bs-0061R) at 1/1000 dilutionLane 2: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane 3: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane 4: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionLane 5: Anti-beta-Actin (bs-0061R) at 1/20000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:HL60 (Human) Cell Lysate at 40 ugHUVEC (Human) Cell Lysate at 40 ugSpinal cord (Rat) Lysate at 40 ugRectum (Rat) Lysate at 40 ugPlacenta (Rat) Lysate at 40 ugLymph node (Rat) Lysate at 40 ugLung (Rat) Lysate at 40 ugSpleen (Rat) Lysate at 40 ugJAR (Human) Cell Lysate at 40 ug293T (Human) Cell Lysate at 40 ugJurkat (Human) Cell Lysate at 40 ugTM4 (Human) Cell Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:A549 (Human) Cell Lysate at 40 ugRaw264.7 (Mouse) Cell Lysate at 40 ugSH-SY5Y (Human) Cell Lysate at 40 ugMKN45 (Human) Cell Lysate at 40 ugCHO (Human) Cell Lysate at 40 ugPanc-1 (Human) Cell Lysate at 40 ug4T1 (Human) Cell Lysate at 40 ugASPC-1 (Human) Cell Lysate at 40 ugH9C2 (Rat) Cell Lysate at 40 ugBrl-3a (Rat) Cell Lysate at 40 ugTT (Human) Cell Lysate at 40 ugTEV-1 (Human) Cell Lysate at 40 ugEC9706 (Human) Cell Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:Embryo Cerebrum (Mouse) Lysate at 40 ugDu145 (Human) Lysate at 40 ugSW480 (Human) Cell Lysate at 40 ugU87MG (Human) Lysate at 40 ugU251 (Human) Lysate at 40 ugA673 (Human) Lysate at 40 ugLovo (Human) Lysate at 40 ug293FT (Human) Lysate at 40 ugJEG-3 (Human) Lysate at 40 ugRSC96 (Rat) Cell Lysate at 40 ugMCF-7 (Human) Cell Lysate at 40 ugHepG2 (Human) Lysate at 40 ugA431 (Human) Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:Thymus (Mouse) Lysate at 40 ugUrinary bladder (Mouse) Lysate at 40 ugUterus (Mouse) Cell Lysate at 40 ugAorta (Mouse) Lysate at 40 ugolfactory bulb (Mouse) Lysate at 40 ugCerebellum (Mouse) Lysate at 40 ugAdrenal gland (Mouse) Lysate at 40 ugOvary (Mouse) Lysate at 40 ugEar (Mouse) Lysate at 40 ugU2os (Human) Cell Lysate at 40 ugASPC-1 (Human) Cell Lysate at 40 ugVas deferens (Mouse) Lysate at 40 ugtrachea (Mouse) Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDSample:Lung (Mouse) Lysate at 40 ugCerebrum (Mouse) Lysate at 40 ugPrimary: Anti-beta-Actin (Loading Control) (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDTissue/cell: human cervical carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;Incubation: Anti-Beta-actin Polyclonal Antibody, Unconjugated(bs-0061R) 1:1500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) stainingTissue/cell: Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (beta-Actin) polyclonal Antibody, Unconjugated (bs-0061R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG-FITC antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.MCF7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (beta-Actin) polyclonal Antibody, Unconjugated (bs-0061R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.MCF7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (beta-Actin) polyclonal Antibody, Unconjugated (bs-0061R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.Blank control: NIH/3T3.Primary Antibody (green line): Rabbit Anti-beta-Actin (Loading Control) antibody (bs-0061R)Dilution: 1μg /10^6 cells;Isotype Control Antibody (orange line): Rabbit IgG .Secondary Antibody : Goat anti-rabbit IgG-AF488Dilution: 1μg /test.ProtocolThe cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.Blank control:Mouse spleen.Primary Antibody (green line): Rabbit Anti-beta-Actin (Loading Control) antibody (bs-0061R)Dilution: 2μg /10^6 cells;Isotype Control Antibody (orange line): Rabbit IgG .Secondary Antibody : Goat anti-rabbit IgG-AF647Dilution: 1μg /test.ProtocolThe cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.Blank control: RSC96(blue).Primary Antibody: Rabbit Anti-beta-Actin /FITC Conjugated antibody (bs-0061R/FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.ProtocolThe cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. The cells were washed twice with 1 X PBS. The cells were incubated in 1 X PBS containing 0.5% BSA + 1 0% goat serum (15 min) to block non-specific protein-protein interactions followed by the incubated with antibody (bs-0061R/FITC, 1μg /1x10^6 cells) for 30 min on ice. Acquisition of 20,000 events was performed.

赛国生物为您提供1997个 赛国生物产品中心 ，如在选择 赛国生物产品中心产品 有疑问可以联系在线客服。

赛国生物产品中心

0.00元

0.00元

0.00元

0.00元

0.00元

0.00元

1098.00元

1098.00元

1098.00元

1098.00元

1098.00元

980.00元

980.00元

4800.00元

980.00元

1098.00元

1098.00元

1098.00元

980.00元

880.00元

热门品牌

推荐品牌

产品与服务

联系方式